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The c.63A>G polymorphism in the NKX2.5 gene is associated with thyroid hypop...

Cerqueira,Taise Lima de Oliveira; Ramos,Yanne; Strappa,Giorgia; Martin,Daniel San; Jesus,Mariana; Gonzaga,Jailciele; Ferreira,Paulo; Costa,Anabel

Objective To search for genetic alteration in NKX2.5 gene in patients presenting both congenital heart disease (CHD) and TD. Subjects and methods Individual phenotypes were carefully analyzed in 86 children with thyroid dysgenesis (TD) using thyroid function tests, scintigraphy, ultrasound and echocardiography. DNA was extracted and NKX2.5 gene coding region was amplified by polymerase chain reaction (PCR) and ...

Date: 2015   |   Origin: Oasisbr
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