11 documents found, page 1 of 2
Effects of exercise on sleep symptoms in patients with severe obstructive sleep...
Silva,Roberto Pacheco da; Martinez,Denis; Bueno,Kelly Silveira da Silva; Uribe-Ramos,Jhoana MercedesABSTRACT Objective: To investigate the extent to which exercise is associated with symptoms in patients with severe obstructive sleep apnea (OSA). Methods: We included subjects with an apnea-hypopnea index (AHI) > 30 events/h who completed validated sleep and exercise questionnaires. We compared symptom frequency/scores between exercisers and nonexercisers, adjusting for the usual confounders. Results: The samp...
Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxie...
Carissimi,Alicia; Martinez,Denis; Kim,Lenise J.; Fiori,Cintia Z.; Vieira,Luciana R.; Rosa,Darlan P.; Pires,Gabriel N.Objective: Sleep apnea has been associated with anxiety, but the mechanisms of the sleep apnea-anxiety relationship are unresolved. Sleep apnea causes oxidative stress, which might enhance anxiety-like behavior in rodents. To clarify the apnea-anxiety connection, we tested the effect of intermittent hypoxia, a model of sleep apnea, on the anxiety behavior of mice. Methods: The rodents were exposed daily to 480 ...
Melatonin prevents hyperglycemia in a model of sleep apnea
Kaminski,Renata Schenkel Rivera; Martinez,Denis; Fagundes,Micheli; Martins,Emerson Ferreira; Montanari,Carolina Caruccio; Rosa,Darlan PaseObjective Obstructive sleep apnea is a common disorder associated with aging and obesity. Apneas cause repeated arousals, intermittent hypoxia, and oxidative stress. Changes in glucolipidic profile occur in apnea patients, independently of obesity. Animal models of sleep apnea induce hyperglycemia. This study aims to evaluate the effect of the antioxidants melatonin and N-acetylcysteine on glucose, triglyceride...
Sleep-disordered breathing in patients with cystic fibrosis
Veronezi,Jefferson; Carvalho,Ana Paula; Ricachinewsky,Claudio; Hoffmann,Anneliese; Kobayashi,Danielle Yuka; Piltcher,Otavio BejzmanAbstractObjective: To test the hypothesis that disease severity in patients with cystic fibrosis (CF) is correlated with an increased risk of sleep apnea.Methods: A total of 34 CF patients underwent clinical and functional evaluation, as well as portable polysomnography, spirometry, and determination of IL-1β levels.Results: Mean apnea-hypopnea index (AHI), SpO2 on room air, and Epworth Sleepiness Scale score w...
Uncoupling protein-2 mRNA expression in mice subjected to intermittent hypoxia
Vieira,Luciana Rodrigues; Martinez,Denis; Forgiarini,Luiz Felipe; Rosa,Darlan Pase da; Muñoz,Gustavo Alfredo Ochs de; Fagundes,MicheliObjective: To investigate the effect of intermittent hypoxia-a model of obstructive sleep apnea (OSA)-on pancreatic expression of uncoupling protein-2 (UCP2), as well as on glycemic and lipid profiles, in C57BL mice. Methods: For 8 h/day over a 35-day period, male C57BL mice were exposed to intermittent hypoxia (hypoxia group) or to a sham procedure (normoxia group). The intermittent hypoxia condition involved ...
Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated ri...
Massierer,Daniela; Martinez,Denis; Fuchs,Sandra Costa; Pellin,Paulo P.; Garcia,Márcio S.; Zacharias,Ana Luisa; Antunes,Isadora F.; Wainstein,Marco V.Obstructive sleep apnea (OSA), a risk factor for coronary artery disease, remains under diagnosed. We investigated if OSA identified by the Berlin Questionnaire (BQ) is associated with the risk of coronary artery disease. Cases were patients referred for elective coronariography. The cases were classified with significant coronary lesions (stenosis > 50% in an epicardial coronary) or without significant coronar...
Consequências cardiovasculares na SAOS
Lorenzi Filho,Geraldo; Genta,Pedro Rodrigues; Pedrosa,Rodrigo Pinto; Drager,Luciano Ferreira; Martinez,DenisUma condição clínica muito comum é SAOS, que está associada a várias doenças cardiovasculares, incluindo hipertensão arterial sistêmica, fibrilação atrial e aterosclerose. A associação entre SAOS e doença cardiovascular não é somente uma consequência da sobreposição de fatores de risco, incluindo obesidade, sedentarismo, ser do sexo masculino e ter idade maior. Existem evidências crescentes de que SAOS contribu...
Dimensions of sleepiness and their correlations with sleep-disordered breathing...
Martinez,Denis; Lumertz,Magali Santos; Lenz,Maria do Carmo SfreddoOBJECTIVE: There are many ways of assessing sleepiness, which has many dimensions. In patients presenting a borderline apnea-hypopnea index (AHI, expressed as events/hour of sleep), the mechanisms of excessive daytime sleepiness (EDS) remain only partially understood. In the initial stages of sleep-disordered breathing, the AHI might be related to as-yet-unexplored EDS dimensions. METHODS: We reviewed the polys...
Diagnóstico dos transtornos do sono relacionados ao ritmo circadiano
Martinez,Denis; Lenz,Maria do Carmo Sfreddo; Menna-Barreto,LuizQueixas de insônia e sonolência excessiva são comuns na investigação dos distúrbios respiratórios do sono; os transtornos do sono relacionados ao ritmo circadiano talvez sejam as causas mais freqüentemente esquecidas no diagnóstico diferencial destes sintomas. Estes transtornos se manifestam por desalinhamento entre o período do sono e o ambiente físico e social de 24 h. Os dois transtornos do sono relacionados...
Síndrome das apnéias-hipopnéias obstrutivas do sono: associação com gênero e ob...
Knorst,Marli Maria; Souza,Fábio José Fabrício de Barros; Martinez,DenisOBJETIVO: Estudar os efeitos de gênero e obesidade e identificar fatores relacionados à sonolência diurna excessiva (SDE) em indivíduos com síndrome das apnéias-hipopnéias obstrutivas do sono (SAHOS). MÉTODOS: Foram selecionados para inclusão no estudo 300 pacientes consecutivos, atendidos em clínica do sono, com índice de apnéia/hipopnéia (IAH) > 10 eventos/hora de sono, que completaram adequadamente a avaliaç...