35 documents found, page 1 of 4
Cryptococcosis by Cryptococcus neoformans/Cryptococcus gattii Species Complexes...
Nascimento,Erika; Barião,Patrícia Helena Grizante; Kress,Marcia Regina von Zeska; Vilar,Fernando Crivelenti; Santana,Rodrigo de CarvalhoAbstract INTRODUCTION: The clinical manifestations of cryptococcosis are usually associated with the infecting agents Cryptococcus neoformans (CN) and C. gattii (CG) species complexes and the host. In this study, non-HIV-infected patients, at a university hospital in southeastern Brazil, had epidemiological and clinical data associated with cryptococcal disease and isolated Cryptococcus species: CN - 24 patient...
Characterization of a Paracoccidioides spp. strain from southeastern Brazil gen...
Cocio,Tiago Alexandre; Nascimento,Erika; Kress,Marcia R. V. Z.; Bagagli,Eduardo; Martinez,RobertoAbstract Phylogenetic species of Paracoccidioides brasiliensis complex (S1a and S1b, PS2, PS3, and PS4) and Paracoccidioides lutzii are agents of paracoccidioidomycosis, an endemic fungal disease in Latin America. P. restrepiensis (PS3 genotype) was classified as monophyletic and geographically restricted to Colombia and neighboring territories. BAT (or Pb-327B) was isolated from a patient living in the southea...
Minimum concentration of Amphotericin B in serum according to the formulation, ...
Schiave,Leticia Aparecida; Nascimento,Erika; Gaspar,Gilberto Gambero; Vilar,Fernando Crivelenti; Martinez,Edson Zangiacomi; Gaitani,Cristiane Masetto deAbstract INTRODUCTION: The therapeutic efficacy of daily amphotericin B infusion is related to its maximum concentration in blood; however, trough levels may be useful in intermittent regimens of this antifungal drug. METHODS : High performance liquid chromatography (HPLC) was used to determine the minimum concentration (Cmin) of amphotericin B in the serum of patients receiving deoxycholate (D-Amph) or liposom...
Human pulmonary dirofilariasis with secondary myocarditis
Doltrário,Andréa Beltrami; Valim,Natalí Caneli; Dellaspora,Ellen Aparecida Pereira Barboza; Gaspar,Gilberto Gambero; Puga,Fernanda GuiotiAbstract Dirofilariasis is a little-known zoonosis, with dogs and cats as definitive hosts. It is caused by nematodes and transmitted by mosquito bites. We report the case of a 67-year-old man with a consumptive syndrome with two subpleural pulmonary opacities. A transthoracic lung biopsy revealed a Dirofilaria worm. Myocardial nuclear magnetic resonance (NMR) demonstrated dilated cardiomyopathy after myocardit...
Fluconazole levels in serum and cerebrospinal fluid according to daily dosage i...
Schiave,Letícia Aparecida; Nascimento,Erika; Vilar,Fernando Crivelenti; de Haes,Tissiana Marques; Takayanagui,Osvaldo MassaitiABSTRACT Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid. In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AIDS and 13 had neurocryptococcosis. The only selection criterion was treatment with fluconazole, which was per...
Is community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) a...
Paternina-de la Ossa,Rolando; Prado,Seila Israel do; Cervi,Maria Célia; Lima,Denissani Aparecida Ferrari dos Santos; Martinez,RobertoABSTRACT Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is spreading worldwide, but little is known about the epidemiology of this pathogen in Brazil. Objective: To evaluate clinical and microbiological features of children with S. aureus infections admitted to a university hospital. Methods: This was a cross-sectional study evaluating the potential risk factors for CA-MR...
Brazilian guidelines for the clinical management of paracoccidioidomycosis
Shikanai-Yasuda,Maria Aparecida; Mendes,Rinaldo Pôncio; Colombo,Arnaldo Lopes; Queiroz-Telles,Flávio de; Kono,Adriana Satie GonçalvesAbstract Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in seri...
Molecular analysis of methicillin-resistant Staphylococcus aureus dissemination...
Okado,Jessica Baleiro; Bogni,Simoni Camila; Reinato,Lílian Andreia Fleck; Martinez,Roberto; Gir,Elucir; Camargo,Ilana Lopes Baratella da CunhaAbstract INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) is a nosocomial pathogen in community settings. MRSA colonized individuals may contribute to its dissemination; the risk of MRSA infection is increased in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients, although the prevalence of colonization in this group is not well established. The present study ad...
Secular trends in Klebsiella pneumoniae isolated in a tertiary-care hospital: i...
Santana,Rodrigo de Carvalho; Gaspar,Gilberto Gambero; Vilar,Fernando Crivelenti; Bellissimo-Rodrigues,Fernando; Martinez,RobertoAbstract: INTRODUCTION Klebsiella pneumoniae has become an increasingly important etiologic agent of nosocomial infections in recent years. This is mainly due to the expression of virulence factors and development of resistance to several antimicrobial drugs. METHODS This retrospective study examines data obtained from the microbiology laboratory of a Brazilian tertiary-care hospital. To assess temporal trends ...
A randomized clinical trial on the effectiveness of a symbiotic product to deco...
Salomão,Mariana Correa Coelho; Heluany-Filho,Mário Augusto; Menegueti,Mayra Gonçalves; Kraker,Marlieke Elizabeth Adriana De; Martinez,RobertoAbstract INTRODUCTION: We aimed to evaluate the effectiveness of a symbiotic product to decolonize the intestinal tract of patients harboring multidrug-resistant (MDR) Gram-negative bacilli and to prevent nosocomial infections. METHODS: This was a randomized, double blind, placebo-controlled clinical trial, conducted in a tertiary-care university hospital. All adult hospitalized patients with a positive clinica...