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Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDAL...

Bousquet, J.; Melén, E.; Haahtela, T.; Koppelman, G. H.; Togias, A.; Valenta, R.; Akdis, C. A.; Czarlewski, W.; Rothenberg, M.; Valiulis, A.

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...


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