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Comparative efficacy of essential oils against Cutibacterium acnes: effect upon...

Oliveira, AS; Gaspar, C; Rolo, J; Palmeira-de-Oliveira, R; Teixeira, JP; Martinez-de-Oliveira, J; Palmeira-de-Oliveira, A

Objectives: Despite being a commensal of human skin, Cutibacterium acnes plays an important role in the pathogenesis of Acne vulgaris, with the loss of bacterial phylotype diversity being related to disease progression. This study evaluated differences in the virulence profile of C. acnes strains from different phylotypes and investigated the possible phylotype-selective efficacy of essential oils (EOs) from Th...


Thymus mastichina (L.) L. and Cistus ladanifer L. for skin application: chemica...

Oliveira, AS; Rolo, J; Gaspar, C; Ramos, L; Cavaleiro, C; Salgueiro, L; Palmeira-de-Oliveira, R; Teixeira, JP; Martinez-de-Oliveira, J

Ethnopharmacological relevance Thymus mastichina (L.) L. (TM) and Cistus ladanifer L. (CL) are two Portuguese autochthonous species with traditional skin application in folk medicine. TM is majorly known for its antiseptic and wound healing properties, as an external anti-inflammatory agent and for its application in folk cosmetics and hygiene products. Its use in acne vulgaris has also been reported. CL is tra...


Chemical characterization and bioactive potential of Thymus×citriodorus (Pers.)...

Oliveira, AS; Rolo, J; Gaspar, C; Cavaleiro, C; Salgueiro, L; Palmeira-de-Oliveira, R; Ferraz, C; Coelho, S; Pastorinho, MR; Sousa, AC; Teixeira, JP

Ethnopharmacological relevance: Thymus × citriodorus (Pers.) Schreb. is an interspecific hybrid between Thymus pulegioides and Thymus vulgaris, known for its pharmacological activities as diaphoretic, deodorant, antiseptic and disinfectant, the last mostly related with its antimicrobial activity. The folk use of other extracts, as hydrolates, have also been disseminated, as regulators of oily skin with anti-acn...


Thymus mastichina (L.) L. and Cistus ladanifer L. for skin application: chemica...

Oliveira, AS; Rolo, J; Gaspar, C; Ramos, L; Cavaleiro, C; Salgueiro, L; Palmeira-de-Oliveira, R; Teixeira, JP; Martinez-de-Oliveira, J

Ethnopharmacological relevance Thymus mastichina (L.) L. (TM) and Cistus ladanifer L. (CL) are two Portuguese autochthonous species with traditional skin application in folk medicine. TM is majorly known for its antiseptic and wound healing properties, as an external anti-inflammatory agent and for its application in folk cosmetics and hygiene products. Its use in acne vulgaris has also been reported. CL is tra...


Development of a new multiplex PCR to detect prevalent species of house dust mi...

Oliveira, AS; Gaspar, C; Rolo, J; Pereira, CC; Palmeira-de-Oliveira, R; Teixeira, JP; Martinez-de-Oliveira, J; Palmeira-de-Oliveira, A

Dermatophagoides pteronyssinus and Dermatophagoides farinae are the most common House Dust Mite (HDM) species in home environments worldwide and responsible for HDM allergy. Since the prevalence of HDM-related clinical conditions is linked to exposure to the mite itself, the detection of HDM in the human households gains importance. We aimed to develop a fast and accessible multiplex PCR to detect and distingui...


Lactobacillus crispatus as the etiological agent in cytolytic vaginosis

Gaspar, C; Rolo, J; Donders, G; Vieira, Luís; Palmeira-de-Oliveira, R; Martinez-de-Oliveira, J; Palmeira-de-Oliveira, A

Introduction: Lactobacillus spp. dominate the vaginal niche but can also be involved in other vaginal dysbiosis, such as cytolytic vaginosis (CV), which remains poorly studied. It is characterized by a cryptic symptomatology, that often confounds the clinic. Goals: The aim of this work was to search for the etiological agent of CV, by studying the vaginal microbiome and metabolomics of women afflicted with this...


High frequency of CHD7 mutations in congenital hypogonadotropic hypogonadism

Gonçalves, CI; Patriarca, FM; Aragüés, JM; Carvalho, D; Fonseca, F; Martins, S; Marques, O; Pereira, BD; Martinez-de-Oliveira, J; Lemos, MC

Congenital hypogonadotropic hypogonadism (CHH) is characterized by lack of normal pubertal development due to deficient gonadotropin-releasing hormone (GnRH) secretion or action, and is caused by genetic defects in several genes. Mutations in the CHD7 gene cause CHARGE syndrome (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth and development, Genital hypoplasia and Ear abnormal...


High frequency of CHD7 mutations in congenital hypogonadotropic hypogonadism

Gonçalves, CI; Patriarca, FM; Aragüés, JM; Carvalho, D; Fonseca, F; Martins, S; Marques, O; Pereira, BD; Martinez-de-Oliveira, J; Lemos, MC

Congenital hypogonadotropic hypogonadism (CHH) is characterized by lack of normal pubertal development due to deficient gonadotropin-releasing hormone (GnRH) secretion or action, and is caused by genetic defects in several genes. Mutations in the CHD7 gene cause CHARGE syndrome (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth and development, Genital hypoplasia and Ear abnormal...


Prevalence of bacterial vaginosis in Portuguese pregnant women and vaginal colo...

Machado, D; Castro, J; Martinez-de-Oliveira, J; Nogueira-Silva, C; Cerca, N

BACKGROUND: We aimed to determine the prevalence of vaginal colonization by Gardnerella vaginalis and of bacterial vaginosis (BV) in Portuguese pregnant women, and to identify risk factors for BV and G. vaginalis colonization in pregnancy. METHODS: A cross-sectional study was conducted among pregnant women aged ≥ 18 years who were attending in two public hospitals of the Northwest region of Portugal. Epidemiolo...


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