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Hematological evaluation in males with obstructive sleep apnea before and after...

Feliciano, Amélia; Linhas, R.; Marçôa, R.; Cysneiros, A.; Martinho, C.; Reis, R. P.; Penque, D.; Pinto, P.; Bárbara, Cristina

Obstructive sleep apnea syndrome (OSAS) is a systemic inflammatory disease associated with cardiovascular consequences. Red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) are recognized biomarkers of cardiovascular morbidity/mortality. Limited data is available on the association between these parameters and OSAS severity and the relationship with positive...


Effects of positive airway pressure therapy on cardiovascular and metabolic mar...

Feliciano, A.; Oliveira, M.J.; Cysneiros, A.; Martinho, C.; Reis, R.P.; Penque, D.; Pinto, P.; Bárbara, C.

Introduction Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular/metabolic complications. Some analytical parameters (homocysteine, glycemic and lipidic profiles) are recognized markers of these consequences. Limited data is available on the association of these markers and OSAS's severity/response to positive airway pressure therapy (PAP). Material and methods In this prospective study we...


Effects of CPAP on nitrate and norepinephrine levels in severe and mild-moderat...

Pinto, Paula; Bárbara, Cristina; Montserrat,  Josep M.; Patarrão, Rita; Guarino, Maria P.; Carmo, Miguel Mota; Macedo, Maria P.; Martinho, C.

Background: Reduced plasma nitrate (NOx) levels and increased urinary norepinephrine (U-NE) levels have been described in severe obstructive sleep apnea (OSA), and are reverted by continuous positive airway pressure (CPAP). The effect of CPAP on these biomarkers in mild-moderate OSA is not well understood. The aim of this study was to compare NOx and U-NE levels and blood pressure (BP) between male patients wit...


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