2 documents found, page 1 of 1
The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Br...
Francisco, Stephany; Martinho, Vera C.; Ferreira, Margarida; Reis, Andreia; Moura, Gabriela; Soares, Ana Raquel; Santos, Manuel A. S.Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...
Unraveling the Nanoscopic Organization and Function of Central Mammalian Presyn...
Carvalhais, Lia G.; Martinho, Vera C.; Ferreiro, Elisabete; Pinheiro, Paulo S.The complex, nanoscopic scale of neuronal function, taking place at dendritic spines, axon terminals, and other minuscule structures, cannot be adequately resolved using standard, diffraction-limited imaging techniques. The last couple of decades saw a rapid evolution of imaging methods that overcome the diffraction limit imposed by Abbe's principle. These techniques, including structured illumination microscop...