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Hepatic Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease (SOS/VOD) Primar...
Sousa-Pimenta, Mário; Martins, Ângelo; Estevinho, Leticia M.; Vaz, Carlos; Leite, Luís; Mariz, JoséHepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a major complication following hematopoietic stem cell transplantation, resulting from immune and chemical toxicity in the sinusoidal endothelium and hepatocellular damage. In the most severe cases, multiorgan dysfunction occurs, so it is essential to promptly identify patients at greater risk of SOS/VOD and to adopt prophylactic strate...
Oxidative stress and inflammation in B-Cell lymphomas
Sousa-Pimenta, Mário; Estevinho, Maria Manuela; Dias, Miguel Luís Sousa; Martins, Ângelo; Estevinho, Leticia M.Mature lymphoid neoplasms arise de novo or by the transformation of more indolent lymphomas in a process that relies on the stepwise accumulation of genomic and transcriptomic alterations. The microenvironment and neoplastic precursor cells are heavily influenced by pro-inflammatory signaling, regulated in part by oxidative stress and inflammation. Reactive oxygen species (ROSs) are by-products of cellular meta...
Family, migration, domestic work and gender inequalities
Rodrigues, Sónia; Martins, Tiago; Martins, ÂngeloGender Differences are understood as the psychological, social and cultural differences between male and female individuals, the Family being a group of people directly linked by kinship ties, in which adults assume the responsibility of caring for the children, bringing work back to the socio-professional aspects of the individual's life, where all the dynamics of social life unfolds, i.e., it is from here tha...
Bundle Approach to Reduce Bloodstream Infections in Neutropenic Hematologic
Martinez, Jose Manuel; Leite, Luís; França, Daniela; Capela, Rita; Viterbo, Luísa; Varajão, Natalina; Martins, Ângelo; Oliveira, IsabelIntroduction: The objective of the study was to reduce, by a bundle of interventions, the global bloodstream infections and catheterrelated bloodstream infections rates in neutropenic hematology patients with a long-term central venous catheter.Material and Methods: This was a non-randomized prospective study. It was conducted in a 20-bed hematology oncology unit (Portuguese Institute of Oncology, Porto, Portug...
Adulthood Langerhans Cell Histiocytosis: Experience of Two Portuguese Hospitals
Brito, Margarida Dantas de; Martins, Ângelo; Andrade, Joaquim; Guimarães, José; Mariz, JoséIntroduction: Langerhans cell histiocytosis is a heterogeneous disease, more frequently diagnosed during childhood. Between 1/2001 and 12/2013, 20 adult patients were admitted at both Hospitals. This work aimed at ccharacterizing this population.Material and Methods: Retrospective study, review of clinical records.Results: 16 patients were eligible to analysis. The median age at diagnosis was 34 years (15-48); ...
Família, migração, trabalho doméstico e desigualdades de género
Rodrigues, Sónia; Martins, Tiago; Martins, ÂngeloEntendendo-se por Diferenças de Género as diferenças psicológicas, sociais e culturais entre indivíduos do sexo masculino e feminino, sendo a Família um grupo de pessoas unidas directamente por laços de parentesco, no qual os adultos assumem a responsabilidade de cuidar das crianças, remontando o trabalho para os aspectos socioprofissionais da vida do indivíduo, onde se desenrola toda a dinâmica da vida social,...