96 documents found, page 1 of 10
A Rare Case of Multidermatomal Herpes Zoster
Ribeiro Fernandes, Soraia; Martins, Albino; Vilar Santos, Susana; de Faria, Rita; Vila Real Fernandes, JoãoN/A; N/A
The effect of conditioned medium from human amniotic membrane-derived mesenchym...
Silva, C. S.; Casanova, Marta Alexandra Rodrigues; Ferreirinha, P.; da Silva Morais, A.; Osório, H.; Lima, A. C.; Fangueiro, J. F.; Cerqueira, M. T.Aims: The development and selection of T cells occur within the thymus. This organ involutes throughout life, compromising the generation of T cells and, consequently, the efficacy of the immune system. Mesenchymal stem cells (MSC) have beneficial effects on the immune system. Therefore, MSC have been applied in different pathologies related with thymic function. However, there is a lack of knowledge on the pot...
Diaphragmatic hernia repair porcine model to compare the performance of biodegr...
Scuglia, Marianna; Frazão, Laura P.; Miranda, Alice Augusta Macedo; Martins, Albino; Barbosa-Sequeira, Joana; Coimbra, Diana; Longatto, AdhemarBackground Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model. Methods Twelve male pigs were randomly assigned to 3 diferent groups of 4 an...
COX-2 inhibitor delivery system aiming intestinal inflammatory disorders
Oliveira, Ana Isabel; Rodrigues, Luísa Cidália Guimarães; Soares da Costa, Diana; Fernandes, E. M.; Reis, R. L.; Neves, N. M.; Leão, P.; Martins, AlbinoSelective COX-2 inhibitors such as etoricoxib (ETX) are potentially indicated for the treatment of intestinal inflammatory disorders. However, their systemic administration provokes some off-site secondary effects, decreasing the desirable local effectiveness. To circumvent such limitations, herein an ETX delivery system based on electrospun fibrous meshes (eFMs) was proposed. ETX at different concentrations (1...
The influence of feeder cell-derived extracellular matrix density on thymic epi...
Silva, Catarina S.; Pinto, Rute D.; Pires, R. A.; Correia-Neves, M; Reis, R. L.; Alves, Nuno L.; Martins, Albino; Neves, N. M.The thymus is responsible for the selection and development of T cells, having an essential role in the establishment of adaptive immunity. Thymic epithelial cells (TECs) are key players in T cell development interacting with thymocytes in the thymic 3D environment. Feeder-layer cells have been frequently used as platforms for the successful establishment of TEC cultures. Nevertheless, the role of the feeder ce...
Functional recovery of injured cavernous nerves achieved through endogenous ner...
Casanova, Marta R.; Mota, Paulo; Vala, Helena; Nóbrega, Carmen; Morais, Alain da Silva; Silva, Catarina S.; Barros, Alexandre A.; Reis, R. L.Radical prostatectomy is a highly successful treatment for prostate cancer, among the most prevalent manifestations of the illness. Damage of the cavernous nerve (CN) during prostatectomy is the main cause of postoperative erectile dysfunction (ED). In this study, the capability of a personalized bioactive fibrous membrane to regenerate injured CN was investigated. The fibrous membrane bioactivity is conferred ...
Development of bilayered porous silk scaffolds for thymus bioengineering
Silva, Catarina S.; Kundu, Banani; Gomes, Joana M.; Fernandes, Emanuel Mouta; Reis, R. L.; Kundu, Subhas C; Martins, Albino; Neves, N. M.The thymus coordinates the development and selection of T cells. It is structured into two main compartments: the cortex and the medulla. The replication of such complex 3D environment has been challenged by bioengineering approaches. Nevertheless, the effect of the scaffold microstructure on thymic epithelial cell (TEC) cultures has not been deeply investigated. Here, we developed bilayered porous silk fibroi...
Fucoidan from Fucus vesiculosus inhibits inflammatory response, both in vitro a...
Wang, Lingzhi; Oliveira, Ana Catarina Freitas Salazar; Li, Qiu; Ferreira, Andreia S.; Nunes, Cláudia; Coimbra, Manuel A.; Reis, R. L.; Martins, AlbinoFucoidan has been reported to present diverse bioactivities, but each extract has specific features from which a particular biological activity, such as immunomodulation, must be confirmed. In this study a commercially available pharmaceutical-grade fucoidan extracted from Fucus vesiculosus, FE, was characterized and its anti-inflammatory potential was investigated. Fucose was the main monosaccharide (90 mol%) ...
Sulfated seaweed polysaccharides
Inácio, Ana Rita Matos; Carvalho, Ana C.; Oliveira, Catarina; Reys, Lara Priscila Lopes; Silva, Simone S.; Neves, N. M.; Martins, Albino; Reis, R. L.Mankind has used natural resources for many different applications, from food and clothes to drugs, but only recently is giving the due attention to the need for a responsible management of these resources toward sustainability. One of the approaches is to take the most out of its resources, addressing the several components of natural resources, which can be used in many industrial fields. In this regard, many...
Bioactive fibrous membrane containing endogenous nerve growth factor promotes c...
Mota, Paulo; Casanova, Marta; Vala, Helena; Nóbrega, Carmen; da Silva Morais, Alain; Silva, Catarina; Anacleto, Sara; Barros, Alexandre; Reis, R. L.Introduction And Objective Prostate cancer is a frequent disease and the radical prostatectomy one of the most used treatment when the cancer is localized. This procedure commonly causes erectile dysfunction (ED) by injure the cavernous nerve (CN) during the surgery.With this research we investigate the ability of a bioactive fibrous membrane (FM) to regenerate the damaged CN in a rat model of CN injury. Method...