9 documents found, page 1 of 1
In vitro studies on Bothrops venoms cytotoxic effect on tumor cells
Jorge, Roberta J. B.; Martins, Alice M. C.; Morais, Isabel C. O.; Ximenes, Rafael M.; Rodrigues, Felipe A. R.; Soares, Bruno M.Made available in DSpace on 2022-04-29T02:17:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-29; Background: Animal venoms are complex mixtures of proteins and non proteins components with several biological activities. Snake venoms represent an essentially unexplored source of bioactive compounds that may cure disease conditions which do not respond to currently available therapies. These venoms p...
Crotacetin, a Novel Snake Venom C-Type Lectin Homolog of Convulxin, Exhibits an...
Rádis-Baptista, Gandhi; Moreno, Frederico Bruno Mendes Batista; Nogueira, Lucas de Lima; Martins, Alice M. C.; Toyama, Daniela de OliveiraSnake venom (sv) C-type lectins encompass a group of hemorrhagic toxins that are capable of interfering with blood stasis. A very well-studied svC-type lectin is the heterodimeric toxin, convulxin (CVX), from the venom of South American rattlesnake Crotalus durissus terrificus. CVX is able to activate platelets and induce their aggregation by acting via p62/GPVI collagen receptor. By using polymerase chain reac...
Involvement of nitric oxide on bothropoides insularis venom biological effects ...
Menezes, Ramon R. P. P. B.de; Mello, Clarissa P.; Lima, Dânya B.; Tessarolo, Louise D.; Sampaio, Tiago Lima; Paes, Lívia C. F.Viperidae venom has several local and systemic effects, such as pain, edema, inflammation, kidney failure and coagulopathy. Additionally, bothropic venom and its isolated components directly interfere on cellular metabolism, causing alterations such as cell death and proliferation. Inflammatory cells are particularly involved in pathological envenomation mechanisms due to their capacity of releasing many mediat...
L-Aminoacid oxidase from Bothropsleucurus Venom induces nephrotoxicity via apop...
Morais, Gustavo J. S.; Orzáez, M.; Jorge, Roberta J. B.; Bincoletto, Claudia; Toyama, Marcos H.; Monteiro, Helena S. A.; Smaili, Soraya S.Acute renal failure is a common complication caused by Bothrops viper envenomation. In this study, the nefrotoxicity of a main component of B . leucurus venom called L-aminoacid oxidase (LAAO- Bl ) was evaluated by using tubular epithelial cell lines MDCK and HK-2 and perfused kidney from rats. LAAO- Bl exhibited cytotoxicity, inducing apoptosis and necrosis in MDCK and HK-2 cell lines in a concentration-depend...
Study of visceral antinociceptive potential of bee Apis mellifera venom
Costa, Marcus F. B.; Campos, Adriana R.; Abdon, Ana P. V.; Vasconcelos, Renata P.; Castro, Carolina A.; Toyama, Marcos Hikari [UNESP]Made available in DSpace on 2016-04-01T18:45:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2016-04-01T18:50:17Z : No. of bitstreams: 1 ISSN1996-0816-2014-08-30-781-785.pdf: 153104 bytes, checksum: 94407d11c863ce22eb581ffdadf8a7e3 (MD5); Pain is one of the most common reasons for patients to seek medical care. Bee Apis mellifera venom (AMV) has traditionally been used to trea...
L-Aminoacid oxidase from bothrops leucurus venom Induces nephrotoxicity via apo...
Morais, Isabel C. O.; Pereira, Gustavo J. S.; Orzáez, M.; Jorge, Roberta J. B.; Bincoletto, Claudia; Toyama, Marcos H. [UNESP]; Monteiro, Helena S. A.Made available in DSpace on 2015-12-07T15:33:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2015. Added 1 bitstream(s) on 2015-12-07T15:53:26Z : No. of bitstreams: 1 PMC4508040.pdf: 3122617 bytes, checksum: eefcb7bc8aa0ae64a01eff72ad743fb7 (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquis...
Study of visceral antinociceptive potential of bee Apis mellifera venom
Costa, Marcus F. B.; Campos, Adriana Rolim; Abdon, Ana Paula Vasconcellos; Vasconcelos, Renata P.; Castro, Carolina A.; Toyama, Marcos H.Pain is one of the most common reasons for patients to seek medical care. Bee Apis mellifera venom (AMV) has traditionally been used to treat inflammatory diseases and the alleviation of pain. Herein, we aimed to investigate the visceral antinociceptive potential of A. mellifera bee venom and its possible mechanism of action. Acetic acid-induced writhing assay was used in mice to determine the degree of viscera...
Larvicidal activity of the water extract of Moringa oleifera seeds against Aede...
Ferreira, Paulo M. P.; Carvalho, Ana F. U.; Farias, Davi F.; Cariolano, Nara G.; Melo, Vânia M. M.; Queiroz, Maria G. R.; Martins, Alice M. C.Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:49:34Z No. of bitstreams: 1 S0001-37652009000200007.pdf: 536011 bytes, checksum: 846642c2588a4bd24f90ee703c7ddc86 (MD5); Made available in DSpace on 2013-08-22T18:49:35Z (GMT). No. of bitstreams: 1 S0001-37652009000200007.pdf: 536011 bytes, checksum: 846642c2588a4bd24f90ee703c7ddc86 (MD5) Previous issue date: 2009-06-01; Made availabl...
Effects of Bixa orellana L. Seeds on Hyperlipidemia
Ferreira, Jamile M.; Sousa, Daniel F.; Dantas, Mariana Brito; Fonseca, Said G. C.; Menezes, Dalgimar B.; Martins, Alice M. C.Bixa orellana L., urucum, or urucu, a native tropical tree of Central and South American rain forests is used to treat various diseases in popular medicine. In Ceará, Northeast of Brazil, the seeds of urucum have been used for the treatment of high lipid blood levels. The present study investigated the effects of the aqueous extract from Bixa orellana seeds (AEBO) in mice with hyperlipidemia induced by tyloxapo...