28 documents found, page 1 of 3
Efeitos renais induzidos pelo sobrenadante de macrofagos estimulados pelo venen...
Martins, Alice Maria CostaThe genus Crotalus is responsible annually for approximately 1500 cases of snakebite in Brazil. The most common complication in the lethal cases is acute renal failure, but the effects are not completely well understood. In this work, we have examined the renal effects caused by the supernatant of macrophages stimulated by Crotalus durissus cascavella venom as well as the potential role of the inflammatory medi...
Alterações renais causadas pelo veneno de crotalus durissus cascavella e bloque...
Martins, Alice Maria CostaThe ophidian accidents caused by Crotalus snakes have great importance for their toxicity and sequelae. Crotalus durissus cascavella is a common sub- specie in the northeast of Brazil. Wistar rats weighting between 240 and 280g were anaesthetized with sodium pentobarbital (50mg/kg). The right renal artery was cannulated through the upper mesenteric artery (Bowman, RH & Maack, T.E., Amer. J. Physiol. 226: 426-43...
K+ATP channels-independent analgesic action of Crotalus durissus cumanensis venom
Pereira, Ticiana Praciano; Campos, Adriana Rolim; Leal, Luzia Kalyne A. M.; Pierdoná, Taiana Magalhães; Toyama, Marcos H. [UNESP]Made available in DSpace on 2022-04-28T21:24:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01; The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect durin...
Correlation between functional capacity and oxidative stress and inflammation i...
Silva, Ítalo Caldas; Marizeiro, Débora Fortes; Daher, Elizabeth de Francesco; Sandes-Freitas, Tainá Veras de; Meneses, Gdayllon CavalcanteIntroduction: Patients with chronic kidney disease (CKD) may present impaired functional capacity due to peripheral muscle involvement. Oxidative stress and inflammation are probably involved in this pathophysiology. This study aimed to evaluate the association between functional capacity and biomarkers of oxidative stress as well as biomarkers of inflammation in patients under chronic hemodialysis therapy. Met...
Veneno de Bothrops erythromelas ( Amaral, 1923 ) induz apoptose em células epit...
Sousa, Fabíola Carine Monteiro de; Jorge, Antônio Rafael Coelho; Menezes, Ramon Róseo Paula Pessoa Bezerra de; Torres, Alba Fabíola CostaBothrops erythromelas is responsible for a large number of snakebite incidents in Northeastern Brazil. Previously, we showed the effects of whole B. erythromelas venom in an isolated kidney model. To continue the study with B. erythromelas venom, the present work aims to study the effects of this venom on MDCK tubular epithelial cells and assess gene expression involved in kidney injury, aiming at elucidating t...
Atenção à saúde do idoso na prevenção de doenças cardiovasculares (FF00.2003.AI...
Pedrosa, Carina Cavalcante; Silva, Brenna Pinheiro; Azevedo, Isabella Evelyn Prado de; Menezes, Ramon Róseo Paula Pessoa Bezerra de; Sampaio, Tiago LimaO rápido envelhecimento da população brasileira requer grandes mudanças no modo como as práticas em saúde são realizadas, com ênfase em diagnosticar e tratar corretamente as doenças associadas à terceira idade. A Doença Cardiovascular (DCV) é altamente prevalente, sendo a principal causa de óbito em pacientes com mais de 65 anos. Dessa forma, o diagnóstico e tratamento dessa doença devem ser realizados de forma...
Endothelial activation is associated with albuminuria in multibacillary leprosy
Tessarolo, Louise Donadello; Meneses , Gdayllon Cavalcante; Bezerra, Gabriela Freire; Rocha, Thaiany Pereira da; Azevedo, Isabella Evelyn Prado deLeprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 t...
Novel kidney injury biomarkers in tropical infections: a review of the literature
Meneses, Gdayllon Cavalcante; Silva Junior, Geraldo Bezerra da; Tôrres, Paulo Pacelli Bezerra Filizola; Castro, Valeska Queiroz de; Lopes, Renata LimaTropical diseases are mainly found in the tropical regions of Asia, Africa and Latin America. They are a major Public Health problem in these regions, most of them are considered neglected diseases and remain as important contributors to the development of AKI (Acute Kidney Injury), which is associated with increased patients’ morbidity and mortality. In most countries, kidney disease associated to tropical dis...
Molecular fractionation with conjugate caps study of the interaction of the ana...
Marinho, Márcia Machado; Santos, Ricardo Pires dos; Bezerra, Eveline Matias; Costa, Roner Ferreira; Figueira, Ciro Siqueira; Martins, Alice Maria CostaObjective: The objective of this study was to use the molecular fractionation with conjugate caps (MFCC) method to elucidate the possible interaction mechanism of anacardic acid (AA) with the saturated alkyl chain (AA0) in the Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase (TcGAPHD) enzyme. Methods: Initially, the geometry optimization of the AA three-dimensional structure (with the pentadecyl chain...
Novel kidney injury biomarkers in tropical infections: a review of the literature
Meneses, Gdayllon Cavalcante; Silva Junior, Geraldo Bezerra da; Tôrres, Paulo Pacelli Bezerra Filizola; Castro, Valeska Queiroz de; Lopes, Renata LimaTropical diseases are mainly found in the tropical regions of Asia, Africa and Latin America. They are a major Public Health problem in these regions, most of them are considered neglected diseases and remain as important contributors to the development of AKI (Acute Kidney Injury), which is associated with increased patients’ morbidity and mortality. In most countries, kidney disease associated to tropical dis...