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An ab initio explanation of the activation and antagonism strength of an AMPA-s...
Martins, Ana Caroline Vieira; Lima Neto, Pedro de; Barroso Neto, Ito Liberato; Cavada, Benildo Sousa; Freire, Valder NogueiraWe report quantum biochemistry calculations focusing on the binding pocket of the glutamate receptor co-crystallized with agonists (full and partial) and a antagonist. The calculated electronic binding energy follows the order AMPA . glutamate. kainate . DNQX, which explains published experimental data on GluR2 activation and antagonism strength.
Date: 2020
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Origin: Oasisbr