7 documents found, page 1 of 1
Exenatide and Dapagliflozin Combination Enhances Sertoli Cell Secretion of Key ...
Ribeiro, João C.; Martins, Ana D.; Jarak, Ivana; Carvalho, Rui A.; Alves, Marco G.; Oliveira, Pedro F.The incidence of metabolic diseases such as type 2 diabetes mellitus (DM) and obesity has been increasing dramatically. Both diseases are closely linked and new approaches for type 2 DM treatment aim to enable weight loss. A combined therapy of dapagliflozin and exenatide has been used against type 2 DM, influencing allbody glucose dynamics. Spermatogenesis is highly dependent on the metabolic cooperation estab...
Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testi...
Silva, Joana V.; Santiago, Joana; Matos, Bárbara; Henriques, Magda C.; Patrício, Daniela; Martins, Ana D.; Duarte, José A.; Ferreira, RitaAging is associated with testicular morphological and functional alterations, but the underlying molecular mechanisms and the impact of physical exercise are poorly understood. In this study, we examined the effects of age and lifelong moderate-intensity exercise on rat testis. Mature adults (35 weeks) and middle-aged (61 weeks) Wistar Unilever male rats were maintained as sedentary or subjected to a lifelong m...
Metabolic dynamics of human Sertoli cells are differentially modulated by physi...
Martins, Ana D.; Monteiro, Mariana P.; Silva, Branca M.; Barros, Alberto; Sousa, Mário; Carvalho, Rui A.; Oliveira, P.F.; Alves, Marco G.Obesity incidence has pandemic proportions and is expected to increase even further. Glucagon-like peptide-1 (GLP-1) based therapies are well-established pharmacological resources for obesity treatment. GLP-1 regulates energy and glucose homeostasis, which are also crucial for spermatogenesis. Herein, we studied the GLP-1 effects in human Sertoli cells (hSCs) metabolism and mitochondrial function. hSCs were cul...
Identificação das isoformas Aquaporina 4 e 9 e a sua interação com o CFTR (regu...
Jesus, Tito T.; Bernardino, Raquel L.; Martins, Ana D.; Sá, Rosália; Sousa, Mário; Alves, Marco G.; Oliveira, Pedro F.As células de Sertoli (SCs) formam a barreira hematotesticular (BHT), controlando o microambiente onde a espermatogénese ocorre. O regulador de condutância transmembranar de fibrose cística (CFTR) tem um papel preponderante na fertilidade masculina, pois indivíduos com mutações no gene CFTR são normalmente sub-férteis ou inférteis. Para além de ser responsável pelo transporte de Cl-/HCO3-, o CFTR pode controlar...
Ação da leptina no metabolismo da glucose das células de Sertoli: impacto na fe...
Martins, Ana D.; Moreira, Ana C.; Sá, Rosália; Monteiro, Mariana P.; Sousa, Mário; Carvalho, Rui A.; Silva, Branca M.; Oliveira, Pedro F.Nos últimos anos os hábitos alimentares e o estilo de vida têm vindo a tornar-se pouco saudáveis, favorecendo o desenvolvimento de doenças metabólicas (por exemplo Diabetes tipo 2 e obesidade). A leptina é uma hormona produzida no tecido adiposo responsável pela sensação de saciedade. Os níveis desta hormona estão positivamente relacionados com a quantidade de gordura corporal e têm sido descritos efeitos negat...
Testicular lactate content is compromised in men with Klinefelter Syndrome
Alves, Marco G.; Martins, Ana D.; Jarak, Ivana; Barros, Alberto; Silva, Joaquina; Sousa, Mario; Oliveira, Pedro F.Klinefelter syndrome (KS) is the most common genetic cause of human infertility, but the mechanism(s) responsible for its phenotype remain largely unknown. KS is associated with alterations in body composition and with a higher risk of developing metabolic diseases. We therefore hypothesized that KS men seeking fertility treatment possess an altered testicular metabolism profile that may hamper the nutritional ...
Testicular metabolic biomarkers in men with Klinefelter syndrome
Almeida, Susana P.; Martins, Ana D.; Jarak, Ivana; Barros, Alberto; Silva, Joaquina; Sousa, Mario; Oliveira, Pedro F.; Alves, Marco G.