10 documents found, page 1 of 1
Analysis of the immunoexpression of opioid receptors and their correlation with...
Sousa, Alceu Machado de; Dantas, Thinali Sousa; Silva, Paulo Goberlânio de Barros; Martins, Conceição da Silva; Freire, Gildenio EstevamObjective: Breast cancer is a disease of great concern. The prognosis of this tumor is related to its staging. Opioids are widely used to minimize pain in oncology clinics; however, the relationship between the administration of opioids and their effects on tumor cells has yet to be elucidated. Therefore, this study aimed to evaluate the immunoexpression of mu- (μ) and kappa- (κ) opioid receptors and their corr...
The effect of high concentration of zoledronic acid on tooth induced movement a...
Sousa, Fátima Regina Nunes de; Ferreira, Vanessa Costa de Sousa; Martins, Conceição da Silva; Dantas, Hugo Victor; Sousa, Frederico Barbosa deZoledronic acid (ZA) is often prescribed for osteoporosis or resorptive metabolic bone disease. This study aims to evaluate the effect of ZA on orthodontic tooth movement (OTM) and root and bone resorption and its repercussion on root, periodontal ligament and alveolar bone tissues. The experimental group consisted of 72 Wistar rats divided in four subgroups: Naive, Saline and Zoledronic Acid groups at the conc...
Role of rutin in 5-Fluorouracil-induced intestinal mucositis : prevention of hi...
Fideles, Lázaro de Sousa; Miranda, João Antônio Leal de; Martins, Conceição da Silva; Barbosa, Maria Lucianny Lima; Pimenta, Helder BindáIntestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from Dimorphandra gardneriana, exhibits antioxidant, anti-inflammatory, cytoprotective, and gastroprotective properties. However, the effect of RUT on inflammatory process...
Chitosan membrane modified with a new Zinc(ii)-vanillin complex improves skin w...
Tavares, Emanuella de Aragão; Medeiros, Wendy Marina Toscano Queiroz de; Pontes, Talita Pereira de Assis; Barbosa, Maisie Mitchele BarbosaThe treatment of chronic wounds is considered a public health problem. When the condition affects at-risk groups such as those with diabetics, it becomes a great clinical challenge. In this work, we evaluated the healing effects of a new zinc complex, [Zn(phen)(van)2], identified as ZPV, which was synthesized, characterized and associated with chitosan (CS) membranes and tested on cutaneous wounds of diabetic r...
Alterações induzidas pela toxina A do Clostridium difficile na via WNT/B-cateni...
Martins, Conceição da SilvaClostridium difficile, an agent that causes diarrhea and colitis, produces toxin A (TcdA) and B, two potent enterotoxins. Both toxins reduce proliferation and apoptosis in intestinal epithelial cells. The Wnt-β-catenin pathway, when activated, stimulates the proliferation and differentiation of epithelial cells. In vitro, Clostridium difficile TcdA of has been shown to inhibit the Wnt/β-catenin pathway, even in...
Role of the route of leukotrienes in an experimental model of oral mucositis in...
Silva, Viviane Carvalho da; Leitão, Renata Ferreira de Carvalho; Brito, Gerly Anne de Castro; Martins, Conceição da Silva; Freire, Gildenio EstevamPurpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was administ...
Avaliação in vitro de diferentes agentes de descontaminação de cones de guta-pe...
Freire, Gildênio Estevam; Aguiar, Bernardo Almeida; Veras, Mariana de Oliveira Viana; Ferreira, Arthur Cordeiro; Martins, Conceição da SilvaEndodontic therapy is composed of phases in which the aseptic chain breakage may compromise the treatment success. The sterilization impossibility of gutta-percha cones necessitates their prior decontamination. Thus, this study aimed to evaluate the four chemical agents efficiency in the decontamination of forty-nine gutta-percha cones contaminated with pure and standardized cultures of Enterococcus faecalis st...
Statistical analysis use on determination of associated factors with overweight...
Santos, Rosângela Gomes dos; Lima, Maria Raquel da Silva; Florêncio, Raquel Sampaio; Moura, Felipe Carmo de; Martins, Conceição da SilvaCurrently health population presents tied to different personal and environmental factors that makes complex the study of these relations with diseases that involve different living habits, such as obesity. In order to clarify the impact of different factors on overweight and obesity, different statistical test are used, facilitating a broader view of a likely default multifactorial. Thus, the aim of this study...
Low-Dose naltrexone in diseases’ treatment : global review
Moura, Felipe Carmo de; Martins, Conceição da Silva; Soares, Paula Matias; Brito, Gerly Anne de CastroABSTRACT – Naltrexone is a non - selective opioid antagonist, which shows effects on delta, mu and kappa rece ptors. Its therapeutic use is designed for drug addicts’ treatment, reducing withdrawal side effects. However, several researchers have used low - dose Naltrexone (LDN) for therapeutic purposes in diseases associated to immune system deficiency and inflammat ory and tumor processes. Consequently , enhan...
Aplicação tópica do gel de S-nitrosoglutationa em matriz mucoaderente modula ma...
Martins, Conceição da SilvaPeriodontal diseases, highly prevalent disease in worldwide population, manifest primarily in two distinct entities: plaque-induced gingivitis and periodontitis. In this study, we evaluated the effect of a formulation containing nitric oxide donor, S-nitrosoglutathione (GSNO), in mucoaderente matrix (HPMC) in experimental periodontal disease (EPD). This mucoaderente formulation allows topical application and sl...