16 documents found, page 1 of 2
Antibiofilm and antimicrobial activity of polymyxin derivatives
Lopes, Lúcia; Martins, Elsa; Lopes, Susana P.; Costa, Susana P.Lower tract respiratory infections caused by Gram-negative pathogens classified by the World Health Organization as priority targets (e.g., Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae) pose a global public health concern as they are often mediated by biofilms, including multidrug-resistant strains [1,2]. The rise of antimicrobial resistance in these complicated infections has revived ...
Non-reactive VDRL in secondary syphilis: a clinical case of prozone phenomenon?
Ribau, Rita; Rua, Inês; Martins, ElsaIntroduction: Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. Syphilis is preventable and treatable and can present several manifestations, depending on its stage – primary, secondary, or latent. The prozone phenomenon is a rare situation in which, due to an excess of antibodies in secondary syphilis, the VDRL presents a false-negative qualitative result. This clinical c...
New polymyxin analogs to combat Gram-negative biofilm-associated infections
Graínha, Tânia Raquel Rodrigues; Martins, Elsa; Costa, Susana P.; Jorge, Paula; Lopes, Susana P.Introduction: Antimicrobial resistance is a major global health threat, with which the antibiotic discovery pipeline is not keeping up. Polymyxins (PM), notably B (PMB) and E (PME) have resurrected as last-resort drugs (given their toxicity) against difficult-to-treat Gram-negative bacterial infections (often biofilm-related), but PM resistance has already been reported. In recent years, a fast-growing no. of P...
Synthesis of polymyxin analogs with enhanced activity towards Gram-negative bio...
Grainha, Tânia; Martins, Elsa; Costa, Susana Paula; Jorge, Paula; Lopes, Susana Patrícia[Excerpt] Polymyxins (PM) B and E are last-resort drugs against Gram-negative bacterial infections (often biofilm-related), but resistance and toxicity compromise PM use. A fast-growing no. of PM analogs have been reported, but with varied success in improving PM activity and ameliorating toxicity. ,-Dialkylglycines (DAG), unnatural amino acids, hold unique characteristics (bioactivity, metabolic resistance, hy...
Ddevelopment of next-generation polymyxins targeting problematic gram-negative ...
Graínha, Tânia Raquel Rodrigues; Martins, Elsa; Costa, Susana P.; Jorge, Paula; Lopes, Susana PatríciaAntimicrobial resistance is a major global health threat, with which the antibiotic discovery pipeline is not keeping up. Polymyxins (PM) B and E have resurrected as last-resort drugs (given their toxicity) against Gram-negative bacterial infections, but PM resistance has already been reported, resulting in the lack of effective therapies. Taking advantage of these valuable scaffolds, we set out to design new P...
Novel polymyxin analogs with promising activity against Gram-negative bacterial...
Graínha, Tânia Raquel Rodrigues; Martins, Elsa; Costa, Susana P.; Jorge, Paula; Lopes, Susana PatríciaAntimicrobial resistance is a major global health threat, with which the antibiotic discovery pipeline is not keeping up. Polymyxins (PM) B and E have resurrected as last-resort drugs (given their toxicity) against Gram-negative bacterial infections, but PM resistance has already been reported [1], resulting in the lack of effective therapies. Taking advantage of these valuable scaffolds, we set out to design n...
Incorporation of unnatural alpha,alpha-dialkylglycines in polymyxins: synthesis...
Martins, Elsa; Jorge, Paula; Lopes, Susana Patrícia; Costa, Susana P.Lower respiratory infections caused by Gram-negative pathogens classified by the WHO as priority targets (e.g. Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae) pose a great concern as they are often mediated by recalcitrant polymicrobial biofilms and multidrug resistant (MDR) strains. Current antibiotics, and antibacterial agents in clinical development, remain ineffective against these b...
Trimethylaminuria, a social disease? A case report
Rua, Inês; Ribau, Rita; Fonseca Silva, Mariana; Martins, ElsaTrimethylaminuria or ‘fish odour syndrome’ is a rare and under-recognised disease caused by a deficit of flavin monooxygenase 3 enzyme (FMO3). This disease is characterized by the presence of a fishy smell after the ingestion of foods containing trimethylamine precursors. There are no other relevant physical symptoms, however, the social and psychological consequences may be detrimental. Understanding and diagn...
Negative verbs in Portuguese Sign Language
Carmo, Helena; Silva, Verónica Milagres da; Martins, ElsaThis paper aims to systematize the verbal negation in Portuguese Sign Language (LGP). From the lack of structured information about LGP’s Grammar and linguistic behavior comes out the necessity to study this language in a more detailed way, namely the subject matter. To oppose to this lack linguistic description, the present research gives an analysis and characterization of the structure and formation of verba...
Rastreio Auditivo Neonatal em 17 732 Recém-Nascidos
Gabriel, Teresa; Martins, Elsa; Carvalho, Graciete; Fontes, Nuno; Ramos, Maria José; Peres, Marco; Moura, Ivo; Rêgo, João; Guimarães, AnaIntrodução: A surdez infantil representa uma das anomalias congénitas mais frequentes. Em Portugal, foi desenvolvido o Grupo de Rastreio e Intervenção na Surdez Infantil (GRISI), cujo principal objetivo é implementar um programa de rastreio nacional através da aplicação de técnicas e métodos definidos e semelhantes nos vários hospitais. Objetivos: Analizar a polupação de recém-nascidos rastreados num hospital ...