31 documents found, page 1 of 4
Barrett's paradox of cooperation in the case of quasi-linear utilities
Accinelli, E; Afsar, A; Martins, F; Martins, J; Oliveira, B.M.P.M.; Oviedo, J; Alberto A. Pinto; Quintas, LThis paper fits in the theory of international agreements by studying the success of stable coalitions of agents seeking the preservation of a public good. Extending Baliga and Maskin, we consider a model of N homogeneous agents with quasi-linear utilities of the form u(j) (r(j); r) = r(alpha) - r(j), where r is the aggregate contribution and the exponent alpha is the elasticity of the gross utility. When the v...
Fatores de Risco para Alta Prorrogada por Motivos Sociais: Um Estudo Retrospectivo
Martins, M; Mesquita, A; Carvalho, L; Martins, F; Silva, M; Leitão, H; Nunes, MIntroduction: The hospital setting faces a rate of bed occupation by patients whose discharge is limited by other factors apart from clinical needs. This urges the need for an early identification of the patients at risk of delayed discharge due to social factors in order to reduce expenses and to add value that converts itself into the patient health. The aim of this study was to identify the demographic and c...
Epidemiology of Clostridioides Difficile Infection in Portugal: a Retrospective...
Nazareth, C; Leitão, I; Reis, E; Inácio, H; Martins, F; Ramalheira, E; Cunha, F; Santos, C; Lino, S; Moreira, H; Kruptsala, N; Santos, A; Paixão, LIntroduction: Clostridioides difficile is the main cause of healthcare-associated diarrhea in Europe and North America. The aim of this study was to characterize the epidemiology and clinical burden of Clostridioides difficile infection among hospitalized patients in Portugal. Material and methods: Retrospective study conducted in six public hospital centers in Portugal. All primary Clostridioides difficile inf...
Developing and Validating High-Value Patient Digital Follow-Up Services: a Pilo...
Londral, A; Azevedo, S; Dias, P; Ramos, C; Santos, J; Martins, F; Silva, R; Semedo, H; Vital, C; Gualdino, A; Falcão, J; Lapão, LV; Coelho, PBackground: The existing digital healthcare solutions demand a service development approach that assesses needs, experience, and outcomes, to develop high-value digital healthcare services. The objective of this study was to develop a digital transformation of the patients' follow-up service after cardiac surgery, based on a remote patient monitoring service that would respond to the real context challenges. Me...
ON-FIELD PERFORMANCE TEST AND CALIBRATION OTWO COMMERCIALLY AVAILABLE LOW-COST ...
Chojer, H; Branco, P; Martins, F; Sousa, SIVThe use of low-cost devices for air quality monitoring is rapidly growing, and the reason behind the growth might (at least partially) be the real-time monitoring at a lower fixed and operating cost, ease of use and portability. Nevertheless, the poor data reliability of low-cost sensors (LCS) remains a consid-erable challenge, especially when deployed in real-world conditions. This study aimed to evaluate and ...
Immune Response Model Fitting to CD4 + T Cell Data in Lymphocytic Choriomeningi...
Afsar, A; Martins, F; Bruno M P M Oliveira; Pinto, AAWe make two fits of an ODE system with 5 equations that model immune response by CD4 + T cells with the presence of regulatory T cells (Tregs). We fit the simulations to data regarding gp61 and NP309 epitopes from mice infected with lymphocytic choriomeningitis virus LCMV. We optimized parameters relating to: the T cell maximum growth rate; the T cell capacity; the T cell homeostatic level; and the ending time ...
Hypoxia and macrophages act in concert towards a beneficial outcome in colon ca...
Martins, F; Oliveira, R; Cavadas, B; Pinto, F; Cardoso, AP; Castro, F; Sousa, B; Pinto, ML; Silva, AJ; Adão, D; Loureiro, JP; Pedro, N; Reis, RMIn colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage–cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and th...
Targeting the tumor microenvironment: An unexplored strategy for mutant KRAS tu...
Carvalho, PD; Machado, AL; Martins, F; Seruca, R; Velho, SCurrent evidence strongly suggests that cancer cells depend on the microenvironment in order to thrive. In fact, signals from the surrounding tumor microenvironment are crucial for cancer cells´ aggressiveness, altering their expression profile and favoring their metastatic potential. As such, targeting the tumor microenvironment to impair cancer progression became an attractive therapeutic option. Interestingl...
Data on metabolic profile of insulin-degrading enzyme knockout mice
Borges, D; Meneses, M; Dias, T; Martins, F; Oliveira, PF; Alves, M; Macedo, MInsulin-degrading enzyme (IDE) degrades and inactivates bioactive peptides such as insulin. As insulin is a master regulator of glucose homeostasis, lack of IDE is expected to have a profound impact on both insulin and glucose levels. This article shares data on glucose and insulin homeostasis of control, heterozygous and knockout mice for Ide after 18 weeks of a normal chow diet. This data article is related t...
The GO-DACT Protocol: a Multicentre, Randomized, Double-Blind, Parallel-Group S...
Vieira-Sousa, E; Canhão, H; Alves, P; Rodrigues, AM; Teixeira, F; Tavares-Costa, J; Bernardo, A; Pimenta, S; Pimentel-Santos, F; Gomes, JL; Aguiar, RThe GO-DACT is an investigator-initiated, national, multicentric randomized placebo-controlled double-blinded trial, that assesses dactylitis as primary endpoint. Psoriatic arthritis patients naïve to methotrexate and biologic disease modifying anti-rheumatic drugs, with at least one active dactylitis, were assigned to golimumab in combination with methotrexate or placebo in combination with methotrexate, for 2...