8 documents found, page 1 of 1
Reversal of Diabesity Through Modulating Sympathetic Inputs to Adipose Tissue F...
Melo, Bernardete F.; Sacramento, Joana F.; Lavergne, Julien; Martins, Fátima O.; Rosendo-Silva, Daniela; Panzolini, Clara; Prego, Cláudia S.21\u2010CE18\u20100016 from France and the Horizons Europe PASGRAS project (ref 101080329). Moreover, it was supported by the Research Unit UID/04462: iNOVA4Health\u2014Programa de Medicina Translacional, by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), and BM was funded with a PhD Grant (PD/BD/128336/2017) and JFS, FOM with contracts CEEC IND/02428/2018 and CEECIND/04266/2017, all financially supported...
Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independ...
Martins, Fátima O.; Sacramento, Joana F.; Olea, Elena; Melo, Bernardete F.; Prieto-Lloret, Jesus; Obeso, Ana; Rocher, Asuncion; Matafome, PauloSeveral studies demonstrated a link between obstructive sleep apnea (OSA) and the development of insulin resistance. However, the main event triggering insulin resistance in OSA remains to be clarified. Herein, we investigated the effect of mild and severe chronic intermittent hypoxia (CIH) on whole-body metabolic deregulation and visceral adipose tissue dysfunction. Moreover, we studied the contribution of obe...
Peripheral Dopamine Directly Acts on Insulin-Sensitive Tissues to Regulate Insu...
Tavares, Gabriela; Martins, Fátima O.; Melo, Bernardete F.; Matafome, Paulo N.; Conde, Silvia V.Dopamine is a key regulator of glucose metabolism in the central nervous system. However, dopamine is also present in the periphery and may have direct effects on insulin-sensitive tissues. Dopamine receptor 2 (D2R) agonist bromocriptine is a FDA-approved drug for type 2 diabetes. Herein, we explored the role of peripheral dopamine and its receptors in regulating glucose uptake and metabolism on insulin-sensiti...
A 2 Adenosine Receptors Mediate Whole-Body Insulin Sensitivity in a Prediabetes...
Sacramento, Joana F.; Martins, Fátima O.; Rodrigues, Tiago; Matafome, Paulo N.; Ribeiro, Maria J.; Olea, Elena; Conde, Sílvia V.Epidemiological studies showed that chronic caffeine intake decreased the risk of type 2 diabetes. Previously, we described that chronic caffeine intake prevents and reverses insulin resistance induced by hypercaloric diets and aging, in rats. Caffeine has several cellular mechanisms of action, being the antagonism of adenosine receptors the only attained with human coffee consumption. Here, we investigated the...
Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as t...
Jarak, Ivana; Barosa, Cristina; Martins, Fátima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, João; Viegas, IvanThe positional analysis of hepatic glycogen enrichment from deuterated water (2 H2 O) by 2 H NMR has been applied previously to resolve the contributions of glucose and fructose to glycogen synthesis in rodents fed a high sucrose diet. To further validate this method, this analysis was applied to mice fed with synthetic diets whose carbohydrate components consisted solely of either glucose or fructose.; The aut...
Knockout of insulin-degrading enzyme leads to mice testicular morphological cha...
Meneses, Maria João; Borges, Diego O.; Dias, Tânia R.; Martins, Fátima O.; Oliveira, Pedro F.; Macedo, M. Paula; Alves, Marco G.Insulin-degrading enzyme (IDE) is a zinc metalloprotease responsible for degrading and inactivating several bioactive peptides, including insulin. Individuals without this enzyme or with a loss-of-function mutation in the gene that codifies it, present hyperinsulinemia. In addition, impairment of IDE-mediated insulin clearance is associated with the development of metabolic diseases, namely prediabetes. Althoug...
Brain-Liver Nitric Oxide Axis: A Major Regulatory Player in Insulin Clearance a...
Martins, Fátima O.Tese de doutoramento em Biologia Experimental e Biomedicina, apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra; A incapacidade de regular o metabolism glucídico e lipídico está na base das epidemias mundiais obesidade e diabetes tipo 2 (T2D). O eixo intestino-cérebro-fígado tem um papel fundamental na regulação do metabolismo e a insulina é um componente central nas conexões d...
Disposition of [U-2H7]glucose into hepatic glycogen in rat and in seabass
Martins, Fátima O.; Rito, João; Jarak, Ivana; Viegas, Ivan; Pardal, M. A.; Macedo, M. Paula; Jones, John G.The stimulation of hepatic glycogenesis is a ubiquitous response to a glucose challenge and quantifying its contribution to glucose uptake informs its role in restoring euglycemia. Glycogenesis can be quantified with labeled water provided that exchange of glucose-6-phosphate hydrogen 2 (G6P-H2) and body water via glucose-6-phosphate isomerase, and exchange of positions 4, 5 and 6 hydrogens (G6P-H456) via trans...