ASAS and EULAR recommend the use of an improvement ≥1.1 in ASDAS at 12 weeks to determine the continuation of a bDMARD. However, it is debated whether improvements can occur and whether patients’ characteristics influence (time to) response.
Global climate change has induced a rise in sea surface temperature (SST), although this increase is not uniform across the world. Significant variations exist between coastal and offshore waters, particularly in regions affected by upwelling processes. This study focuses on the Canary Current Upwelling System (CCUS), stretching from Northwest Iberia to Northwest Africa. High-resolution remotely sensed SST data...
Spontaneous subcapsular and perirenal hemorrhage, known as Wunderlich syndrome (WS), is a rare clinical manifestation of polyarteritis nodosa (PAN). We report a case of a 48-year-old male with a history of recurrent episodes of leg muscle tenderness and dysesthesia, bilateral flank pain, painful nodular skin lesions in the lower limbs, weight loss, and difficult-to-control arterial hypertension. The abdominopel...
Las especies invasoras son una de las principales amenazas para la conservación de la biodiversidad en todo el mundo; Portugal no es una excepción. Es esencial cambiar las actitudes y el comportamiento de la población, minimizando la introducción, dispersión y establecimiento de estas especies. La escuela puede contribuir a fomentar comportamientos proambientales en los estudiantes y, cuando está abierta a la c...
A criatividade é considerada uma competência essencial neste século. Indivíduos nascidos na década de 90 - Geração Z - surgem como um potencial humano criativo e correspondem aos atuais estudantes universitários. O Ensino Superior é um patamar de formação essencial para desenvolver competências criativas face aos desafios futuros, apesar de fragilidades que nele persistem perante tal objetivo. Por seu lado, um ...
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Criatividade é considerada uma das competências essenciais ao século XXI. Por seu lado, a universidade torna-se um local privilegiado para a formação de profissionais criativos em qualquer domínio do saber e, assim, para responder aos desafios com a inovação que a sociedade exige. Este artigo é de índole teórica e visa refletir a articulação da relevância da criatividade com o papel do Ensino Superior para fome...
We introduce an evolutionary dynamical model for corruption in a democratic state describing the interactions between citizens, government and officials, where the voting power of the citizens is the main mechanism to control corruption. Three main scenarios for the evolution of corruption emerge depending on the efficiency of the institutions and the social, political, and economic characteristics of the State...
In this work, the effect of the exposure to acids that are usually present in the mouth environment on the tribological behavior of restorative dental microcomposites is evaluated. A commercial microcomposite widely used in dentistry (Filtek Z250) and a strong and a week acid that are part of the mouth environment (hydrochloric and lactic acid, respectively) were chosen for the study. Samples of the microcompos...
The immune system as a host defense system watches the cell growth and division, eliminating cells with antigens different from those present in healthy cells. However, some transformed cells have the capacity, through various mechanisms, to escape the immune system. Genomic instability and some mutations are pointed as possible mechanisms supporting the immunosurveillance escape, as is the case of KRAS mutatio...