41 documents found, page 1 of 5
New records of Lipoptena andaluciensis (Diptera: Hippoboscidae) in the Iberian ...
González, Mikel Alexander; Mateus, Teresa Letra; Rodrigues, Filipa Teixeira; Martins, Filipa; Martínez-Calabuig, Néstor; Saldaña, Ana; Panadero, RosarioSince its first description in southern Spain, Lipoptena andaluciensis (Diptera: Hippoboscidae) has drawn increasing attention due to its uncertain origin and distribution. In this study, we report new records of L. andaluciensis from geographically distant regions, including the Castelo Branco district in Portugal and three different northern Spanish provinces (Lerida, Tarragona, and Aragon). A total of 26 spe...
Metabolism-Targeted Therapy in NSCLC - A New Theranostics Inhalation Approach U...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach u...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Ricardo, Ana Aguiar; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Lactate-coated polyurea-siRNA dendriplex
Martins, Filipa; Arada, Renata; Barros, Hélio; Matos, Paulo; JS, Ramalho; Ceña, Valentin; D. B. Bonifácio, Vasco; G Goncalves, Luis; Serpa, JacintaFunding Information: This work benefited from access to CERMAX, ITQB-NOVA, Oeiras, Portugal with equipment funded by FCT, project AAC 01/SAICT/2016. Funding Information: The institutions are funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020...
Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach u...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolis...
Martins, Filipa; Arada, Renata; Barros, Hélio; Matos, Paulo; Ramalho, José; Ceña, Valentín; Bonifácio, Vasco D.B.; Gonçalves, Luís G.; Serpa, JacintaGlioblastoma (GBM) is a highly lethal disease with limited treatment options due to its infiltrative nature and the lack of efficient therapy able to cross the protective blood-brain barrier (BBB). GBMs are metabolically characterized by increased glycolysis and glutamine dependence. This study explores a novel metabolism-based therapeutic approach using a polyurea generation 4 dendrimer (PURE) surface function...
The mitochondrial genomes of Iberian freshwater and diadromous fishes
Veríssimo, Joana; Curto, Manuel; Alves, Judite; Almeida, Pedro; Aparicio, Enric; Clavero, Miguel; Chaves, Cátia; Fernandez-Delgado, CarlosThe Iberian Peninsula, in southwestern Europe, is home to a distinctive freshwater fish fauna, predominantly composed of endemic species. This is a consequence of the prolonged isolation from western Europe caused by the Pyrenees, the diverse geological and climatic gradients, and the isolation of river basins. Freshwater and diadromous fishes have diversified in the Iberian Peninsula and include 72 currently r...
Neuroscience-Based Nomenclature for Psychotropic Drugs: Four Reasons to Use and...
Gouveia, Afonso; Martins, Filipa; Trindade, Pedro; Jesus, Gustavo; M. Bessa, João; Heitor, Maria João; Câmara Pestana, Luís; Fernandes, Luís AfonsoN/a.; N/a.
Biochar as an Alternative Litter Additive to Mitigate Gaseous Emissions from Br...
Pereira, José L.S.; Martins, Filipa; Bonifácio, Gabriel; Garcia, Carla; Teixeira, José; Trindade, HenriqueBroiler farming is a significant source of gaseous emissions. The aim of this study was to assess the effects of different litter additives on the emission of NH3, N2O, CO2, and CH4 during broiler housing and subsequent manure storage. The gaseous emissions from the housing facilities were evaluated during one fattening cycle in environmentally controlled rooms with three different additives applied to the litt...
The Digital Transition of Healthcare: A Pilot Experience
Amorim, Liliana; Moaris, Joana; Costa, Rui; Castanho, Teresa; Neves, Carolina; Sousa, Maria João; Sousa, Rita; Martins, Filipa; Domingues, RuiThe healthcare context is undergoing a significant transformation, facing a series of complex and unprecedented challenges. This transformation is triggered by accessibility constraints to healthcare services, increased expectations from patients and sing financial burdens. Rather than being seen as unsolvable obstacles, these challenges can be perceived as powerful stimuli, encouraging the search for innovativ...