37 documents found, page 1 of 4

Metabolism-Targeted Therapy in NSCLC - A New Theranostics Inhalation Approach U...

Lung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...

Lactate-coated polyurea-siRNA dendriplex

Funding Information: This work benefited from access to CERMAX, ITQB-NOVA, Oeiras, Portugal with equipment funded by FCT, project AAC 01/SAICT/2016. Funding Information: The institutions are funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020...

Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolis...

Glioblastoma (GBM) is a highly lethal disease with limited treatment options due to its infiltrative nature and the lack of efficient therapy able to cross the protective blood-brain barrier (BBB). GBMs are metabolically characterized by increased glycolysis and glutamine dependence. This study explores a novel metabolism-based therapeutic approach using a polyurea generation 4 dendrimer (PURE) surface function...

Neuroscience-Based Nomenclature for Psychotropic Drugs: Four Reasons to Use and...

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Nomenclatura baseada na neurociência para psicofármacos: quatro razões para a u...

Targeting glutamine availability : a new strategy to treat malignant gliomas

The experimental data included in this thesis are sourced from manuscripts that have been previously published or are currently undergoing preparation for publication. I hereby state that I have fully participated in the conception, execution and in the validation of the experimental work, in the analysis and interpretation of the collected data as well as in the preparation of the manuscripts. The experimental...

Biochar as an Alternative Litter Additive to Mitigate Gaseous Emissions from Br...

Broiler farming is a significant source of gaseous emissions. The aim of this study was to assess the effects of different litter additives on the emission of NH3, N2O, CO2, and CH4 during broiler housing and subsequent manure storage. The gaseous emissions from the housing facilities were evaluated during one fattening cycle in environmentally controlled rooms with three different additives applied to the litt...

The Digital Transition of Healthcare: A Pilot Experience

The healthcare context is undergoing a significant transformation, facing a series of complex and unprecedented challenges. This transformation is triggered by accessibility constraints to healthcare services, increased expectations from patients and sing financial burdens. Rather than being seen as unsolvable obstacles, these challenges can be perceived as powerful stimuli, encouraging the search for innovativ...

Small cell neuroendocrine carcinoma of the larynx: a clinical case and literatu...

Neuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryn...

Desconstruindo a divisão sociedade - natureza : processo colaborativo de cocria...

O módulo “Desconstruindo a divisão Natureza-Sociedade” (8h) da 1ª edição da PósGraduação “Uma Só Saúde/One Health” que teve lugar na Escola Superior Agrária do Instituto Politécnico de Viana do Castelo.