16 documents found, page 1 of 2
Identification and Characterization of Myeloid-Derived Suppressor Cells (MDSC) ...
Rodrigues, Cátia F.; A. Rodrigues, Catarina; Maia, Patrícia; Sousa, M. Emília; Godinho, Inês; Neves, Bruno; Duarte, Iola; Lara Santos, LúcioIntroduction: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate under pathological conditions, such as cancer, and suppress immune responses through various mechanisms. Distinguishing MDSC populations remains challenging due to their shared surface markers with neutrophils and monocytes, complicating accurate identification and quantification. This...
Bioinspired host-tailored polymers based on molecular imprinting for cytokine a...
Ferreira, Bianca; Correa-Duarte, Miguel; Marques, Arcelina; Moreira, Felismina; Martins, GabrielaMolecular imprinting undergone a substantial boost driven by the awareness of molecularly imprinted polymers (MIPs)-ligand recognition skills. In particular, the introduction of natural-based compounds like cyclodextrins into the structural scaffold of synthetic recognition elements attracted great importance as a novel route to design more friendly-environments for protein binding, while promoting higher selec...
Enhanced detection with prussian blue-based nanocubes: a novel electrochemical ...
Santos, Andréa dos; Oliveira, Daniela; Martins, Gabriela; Moreira, Felismina T.C.(Introduction) Early diagnosis of biomarkers is crucial for optimizing treatments and increasing survival rates. Direct and cost-effective assays are important for point-of-care (PoC) testing. Bovine serum albumin (BSA) monitoring indicates liver and kidney function and aids in the assessment of diseases such as cirrhosis and chronic kidney disease. An innovative electrochemical biosensor was developed in which...
Plastic antibody for the diagnosis of acute myocardial infarction
Ricardo, Jacinta; Martins, Gabriela; Moreira, Felismina T.C.(Introduction) Novel application Plastic Antibody that responds to a cardiac biomarker, myoglobin (Myo). Imprint stage with electropolymerization of ortho-phenylenediamine (OPD) in the presence of Myo. Template removal from polymeric matrix digested by trypsin. The films acted as biomimetic artificial antibodies and were fabricated on a screen-printed platinium (Pt) electrode (SPE) modified with electroactive P...
Enhanced detection with Prussian blue-based nanocubes: a novel electrochemical ...
Santos, Andréa dos; Martins, Gabriela; Moreira, FelisminaEarly diagnosis of relevant biomarkers is nowadays crucial for optimizing therapeutic approaches and elevating survival rates. Therefore, the development of straightforward, cost-effective, and user-friendly diagnostic assays holds significant value for use in Point-of-Care (PoC) testing. In this context, employing a nanomaterial-redox probe approach in electrochemical biosensing devices not only enhances sensi...
Flexible, electrochemical skin-like platform for inflammatory biomarker monitoring
Lourenço, Carolina; Moreira, Felismina; Igreja, Rui; Martins, GabrielaAddressing global challenges in wound management has greatly encouraged the emergence of home diagnosis and monitoring devices. This technological shift has accelerated the development of new skin patch sensors for continuous health monitoring. A key requirement is the creation of flexible platforms capable of mimicking human skin features. Here, for the first time, an innovative, highly adaptable electrochemic...
Flexible 2D and 3D conductive hydrogel platforms for wearable applications
Aguiar, Leonor; Pereira, Raquel; Sharma, Sanjiv; Martins, GabrielaHydrogels have risen as exceptionally promising support materials in the development of novel wearable electronic devices. Their remarkable biocompatibility coupled with customizable mechanical features make these biomaterials ideal choices for applications involving direct contact with biological tissues. In this study, a simple and straightforward manufacturing process using bio-sourced polysaccharide chitosa...
Lifelong exercise training promotes the remodelling of the immune system and pr...
Nascimento-Gonçalves, Elisabete; Seixas, Fernanda; Palmeira, Carlos; Martins, Gabriela; Fonseca, Carolina; Duarte, José Alberto; Faustino-Rocha, Ana IThis work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administratio...
FLOW CYTOMETRIC EVALUATION OF PERIPHERAL BLOOD BIOMARKERS FOR SOLID TUMOURS IMM...
Trigo, Ana Catrina; Maia, Patrícia; Godinho, Inês; Rodrigues, Catarina A.; Sousa, Maria Emília; Pires, Ana Marta; Azevedo, Carla; Santos, Lúcio LaraCancer treatment is an area that is constantly being updated, namely with the discovery of immunotherapy as a clinically effective therapeutic modality for various types of cancer. Among these innovative therapies, immune checkpoint inhibitors (ICI) have proven to provide significant and long-lasting responses. However, this response does not occur for all patients, i.e., some patients do not benefit from this ...
New deep eutectic solvent assisted extraction of highly pure lignin from mariti...
Fernandes, Catarina; Melro, Elodie; Magalhaes, Solange; Alves, Luis; Craveiro, Rita; Filipe, Alexandra; Valente, Artur J. M.; Martins, GabrielaLignocellulosic biomass is a renewable and sustainable feedstock, mainly composed of cellulose, hemicellulose, and lignin. Lignin, as the most abundant natural aromatic polymer occurring on Earth, has great potential to produce value-added products. However, the isolation of highly pure lignin from biomass requires the use of efficient methods during lignocellulose fractionation. Therefore, in this work, novel ...