10 documents found, page 1 of 1
Chitosan-based molecularly imprinted polymers for point-of-care C-reactive prot...
Moreira, Beatriz; Calvet, Sofia; Marques, Arcelina; Martins, Gabriela V.Advanced intelligent wound monitoring is emerging as a critical tool in first-line therapy, supported by innovative products that accelerate the healing process. A novel approach based on molecular imprinting technology was developed to detect biomarkers associated with wound inflammation, using biopolymeric materials. In this study, an electrochemical biosensor for the selective detection of C-reactive protein...
Plastic antibody for the diagnosis of acute myocardial infarction
Ricardo, Jacinta; Martins, Gabriela V.; Moreira, Felismina T.C.(Introduction) Myoglobin (Myo) is the first cardiac biomarker to be released into the bloodstream after the onset of symptoms of Acute Myocardial Infarction (AMI), allowing earlier detection of this disease. Novel application based on Plastic Antibody that responds to a cardiac biomarker, Myo. Imprint stage with electropolymerization of ortho-phenylenediamine (OPD) in the presence of Myo. Template removal from ...
Biocompatible and flexible transparent electrodes for skin-inspired sensing
Pereira, Raquel; Martins, Gabriela V.In recent years, flexible electronics have experienced a massive growth as a response to the high demand for new skin-patch sensor devices targeted at personal health-monitoring. In this context, the incorporation of biopolymers into the backbone of these soft systems brings new opportunities in terms of biocompatibility and sustainability performance. However, the suitable integration of a conductive patterned...
Flexible sensing devices integrating molecularly-imprinted polymers for the det...
Martins, Gabriela V.; Riveiro Rodriguez, Antonio; Chiussi, Stefano; Sales, GoretiIn recent years, the development of flexible and wearable devices for healthcare and biomedical applications has become an emerging technological goal, particularly with personalized medicine on the rise. As a response to the increasing demand for in-situ sensing platforms that fulfil some essential requirements like sensitivity, reproducibility and high stability, electrochemical sensors have boosted their way...
Biosensors for European Zoonotic Agents: A Current Portuguese Perspective
Miguéis, Samuel da Costa; Tavares, Ana P. M.; Martins, Gabriela V.; Frasco, Manuela F.; Sales, Maria Goreti FerreiraEmerging and recurrent outbreaks caused by zoonotic agents pose a public health risk. They result in morbidity and mortality in humans and significant losses in the livestock and food industries. This highlights the need for rapid surveillance methods. Despite the high reliability of conventional pathogen detection methods, they have high detection limits and are time-consuming and not suitable for on-site anal...
Paper-based (bio)sensor for label-free detection of 3-nitrotyrosine in human ur...
Martins, Gabriela V.; Marques, Ana C.; Fortunato, Elvira; Sales, M. Goreti F.Over the last years, paper technology has been widely spread as a more affordable, sustainable and reliable support material to be incorporated in the design of point-of-care (POC) diagnostic devices. However, the single work employing a paper-based device for 3-nitrotyrosine (3-NT), a relevant biomarker for oxidative stress (OS) that is a major origin for many diseases, is incapable of reading successfully com...
Paper-based (bio)sensor for label-free detection of 3-nitrotyrosine in human ur...
Martins, Gabriela V.; Marques, Ana C.; Fortunato, Elvira; Sales, Maria Goreti FerreiraOver the last years, paper technology has been widely spread as a more affordable, sustainable and reliable support material to be incorporated in the design of point-of-care (POC) diagnostic devices. However, the single work employing a paper-based device for 3-nitrotyrosine (3-NT), a relevant biomarker for oxidative stress (OS) that is a major origin for many diseases, is incapable of reading successfully com...
A molecularly imprinted sensor for sensitive detection of 8-hydroxy-2'-deoxygua...
Martins, Gabriela V.; Fortunato, Elvira; Fernandes, Helena R.; Sales, M. Goreti F.Early diagnosis of Oxidative Stress (OS) biomarkers can be used as a crucial tool in cancer prevention, treatment and survival. In this context, 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a repair product of oxidized guanine lesions and has been acknowledged as a suitable biomarker of OS1. Under this scope, a simple and sensitive molecularly imprinted (MIP)-based sensor for detection of urinary 8-OHdG has been des...
Preparation of robust polyamide microcapsules by interfacial polycondensation o...
Rosa, Natacha; Martins, Gabriela V.; Bastos, Margarida M S M; Gois, Joana R.; Coelho, Jorge F. J.; Marques, Juliana Filipa Gouveia; Tavares, C. J.Microcapsules produced by interfacial polycondensation of p-phenylenediamine (PPD) and sebacoyl chloride (SC) were studied. The products were characterized in terms of morphology, mean diameter and effectiveness of dodecane encapsulation. The use of Tween 20 as dispersion stabilizer, in comparison with polyvinyl alcohol (PVA), reduced considerably the mean diameter of the microcapsules and originated smoother w...
A biomimetic sensor for monitoring oxidative stress biomarker in point-of-care
Martins, Gabriela V.; Fortunato, Elvira; Fernandes, Helena R.; Sales, M. Goreti F.Free radicals and other reactive species are constantly generated in vivo and can cause oxidative damage to biomolecules, a process that seems to play an important role at the origin of cancer. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a major product of DNA hydroxylation and is considered a biomarker of damage caused by oxidative stress (OS). Thus, early diagnosis of OS biomarkers may be used as a fundamental to...