50 documents found, page 1 of 5
Supramolecular ultra-short carboxybenzyl-protected dehydropeptide-based hydroge...
Veloso, Sérgio R. S.; Jervis, Peter J.; Silva, Joana F. G.; Hilliou, L.; Moura, C.; Pereira, David M; Coutinho, Paulo J. G.; Martins, J. A.Self-assembled peptide-based hydrogels are promising materials for biomedical research owing to biocompatibility and similarity to the extracellular matrix, amenable synthesis and functionalization and structural tailoring of the rheological properties. Wider developments of self-assembled peptide-based hydrogels in biomedical research and clinical translation are hampered by limited commercial availability all...
Bolaamphiphilic Bis-Dehydropeptide hydrogels as potential drug release systems
Amorim, Carolina; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.; Hilliou, L.; Pereira, Renato B.; Pereira, David M.; Martins, J. A.The self-assembly of nanometric structures from molecular building blocks is an effective way to make new functional materials for biological and technological applications. In this work, four symmetrical bolaamphiphiles based on dehydrodipeptides (phenylalanyldehydrophenylalanine and tyrosyldehydrophenylalanine) linked through phenyl or naphthyl linkers (terephthalic acid and 2,6-naphthalenedicarboxylic acid) ...
Advances in nanotheranostics with plasmonic and magnetic nanoparticles
Veloso, Sérgio Rafael Silva; Ferreira, Paula M. T.; Martins, J. A.; Coutinho, Paulo J. G.; Castanheira, Elisabete M. S.Brain drug delivery remains a challenge for nanomedicine owing to a large variety of difficulties, ranging from the blood-brain barrier hindering most of chemotherapeutic drugs to the essential and delicate anatomical structures surrounding the target blocking a proper detection/monitoring of the disease. Magnetic and plasmonic nanoparticles have provided a means for the development of nanotheranostic agents, t...
Termodinâmica para materiais com introdução breve à termodinâmica estatística
Martins, J. A.Este texto começou em 2018/19 com objectivo ambicioso da escrita de umlivro de Química-Física de Materiais. Apercebi-me ao fim do primeiro ano que o volume de páginas desse texto excederia o limite por mim estabelecido para umlivro de texto minimamente transportável (200 páginas). Assim vi-me obrigado a fragmentar o projecto inicial em vários subprojectos. Este texto é um deles. Neste texto pretendo abordar con...
Introdução à física de polímeros
Martins, J. A.Os capítulos 1 e 2 deste texto foram escritos em LaTex em 2020 e incorporados na versão anterior de 2017. O cap. 1 é usado no módulo de polímeros de Eng. de Materiais (1º ano). Os restantes capítulos são ensinados aos alunos no MIEPOL e MIEMAT (2º ano, 2º semestre) no âmbito das disciplinas de Ciência de Polímeros III e Física de Polímeros. O capítulo sobre cristalização é ensinado aos alunos do MIEPOL (3º ano,...
Magnetic dehydrodipeptide-based self-assembled hydrogels for theragnostic appli...
Carvalho, André; Gallo, Juan; Pereira, David M.; Valentão, Patrícia; Andrade, Paula B.; Hilliou, L.; Ferreira, Paula M. T.; Bañobre-López, ManuelSelf-assembled peptide hydrogels have emerged in recent years as the new paradigm in biomaterials research. We have contributed to this field the development of hydrogels based on dehydrodipeptides <i>N</i>-capped with naproxen. The dehydrodipeptide hydrogels can be loaded with drugs, thus being potential nanocarriers for drug delivery. In this work novel dehydrodipeptides containing tyrosine and aspartic acid ...
Química Física de Materiais
Martins, J. A.
Benzyloxycarbonyldehydropeptides hydrogelators for drug delivery
Brandão, D.; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.; Martins, J. A.; Ferreira, Paula M. T.New benzyloxycarbonyldehydropeptides hydrogelators were synthesized. Gelation was attained at 0.3 wt% and pH=7.3. The new hydrogel is promising for drug delivery applications.
Core-shell magnetic-plasmonic nanoparticles enclosed in biocompatible hydrogels...
Veloso, Sérgio Rafael Silva; Ferreira, Paula M. T.; Martins, J. A.; Coutinho, Paulo J. G.; Castanheira, Elisabete M. S.In this work, superparamagnetic manganese ferrite nanoparticles, either coated with a gold shell or decorated with gold nanoparticles, were successfully incorporated into a new self-assembled peptide-derived hydrogel. The new magnetogels were tested as drug nanocarriers and photothermia capabilities were evaluated following the release of a model drug (curcumin).
Core-shell magnetic-plasmonic nanoparticles enclosed in a biocompatible dehydro...
Veloso, Sérgio Rafael Silva; Ferreira, Paula M. T.; Martins, J. A.; Coutinho, Paulo J. G.; Castanheira, Elisabete M. S.The combination of magnetic nanoparticles and hydrogels affords magnetogels, improving the manipulation of physicochemical properties and widening the range of applications, such as magnetic resonance imaging, biosensing, hyperthermia, drug delivery and as a template material. The introduction of plasmonic properties will synergistically enhance anticancer therapeutic strategies on the desired target through ph...