38 documents found, page 1 of 4
Multifunctional magneto-plasmonic lipogel based on peptide hydrogel for applica...
Gomes, Valéria; Veloso, Sérgio R. S.; Carvalho, André; Hilliou, L.; Coutinho, Paulo J. G.; Moura, C.; Martins, J. A. R.; Castanheira, Elisabete M. S.Supramolecular hydrogels, particularly low-molecular-weight peptide hydrogels, are promising drug delivery systems due to their ability to change the solubility, targeting, metabolism and toxicity of drugs. Magneto-plasmonic liposomes, in addition to being remotely controllable with the application of an external magnetic field, also increase the efficiency of encapsulated drug release through thermal stimulati...
Tripeptides featuring dehydrophenylalanine and homophenylalanine: homo- versus ...
Carvalho, André F.; Pereira, Teresa; Oliveira, Carlos; Figueiredo, Pedro; Carvalho, Alexandra; Pereira, David M.; Hilliou, L.; Bañobre-López, ManuelOver the years, our research group developed dehydrodipeptides N-capped with aromatic moieties as protease-resistant efficacious hydrogelators, affording self-assembled hydrogels at low (critical) concentrations. Dehydrotripeptides, with different dipeptide sequences and (D,L) stereochemistry, open a wider chemical space for the development of self-assembled soft nanomaterials. In this work, a small library of ...
New supramolecular hydrogels based on diastereomeric dehydrotripeptide mixtures...
Oliveira, Carlos B. P.; Carvalho, André; Pereira, Renato B.; Pereira, David M.; Hilliou, L.; Jervis, Peter J.; Martins, J. A. R.; Ferreira, Paula M. T.Self-assembly of peptide building blocks offers unique opportunities for bottom-up preparation of exquisite nanostructures, nanoarchitectures, and nanostructured bulk materials, namely hydrogels. In this work we describe the synthesis, characterization, gelation, and rheological properties of new dehydrotripeptides, Cbz-L-Lys(Cbz)-L,D-Asp-∆Phe-OH and (2-Naph)-L-Lys(2-Naph)-L,D-Asp-∆Phe-OH, containing a N-termin...
Development of a dextrin-vitamin D3 micelle nanocarrier for the antimicrobial p...
Machado, Fátima Alexandra Meira; Gama, F. M.; Martins, J. A. R.In this work, an expedite synthesis was developed for a self-assembled micelle carrier for the antimicrobial peptide LL18. Covalent one-pot functionalization of dextrin with succinylated vitamin D3 and succinic anhydride produced an amphiphilic material that undergoes self-assembly into micelles in aqueous medium. Succinylated dextrinvitamin D3 micelles were efficiently loaded with LL18 by electrostatic and hyd...
Unveiling the role of capping groups in naphthalene N-capped dehydrodipeptide h...
Vilaça, Helena; Carvalho, André; Castro, Tarsila Gabriel; Castanheira, Elisabete M. S.; Hilliou, L.; Hamley, Ian; Melle-Franco, ManuelSelf-assembled peptide-based hydrogels are archetypical nanostructured materials with a plethora of foreseeable applications in nanomedicine and as biomaterials. N-protected di- and tri-peptides are effective minimalist (molecular) hydrogelators. Independent variation of the capping group, peptide sequence and side chain modifications allows a wide chemical space to be explored and hydrogel properties to be tun...
Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation ...
Silva, Daniela Correia da; Jervis, Peter John; Martins, J. A. R.; Valentão, Patrícia; Ferreira, Paula M. T.; Pereira, David M.Fisetin (FST) is a dietary flavonol that is known to possess multiple relevant bioactivities, raising the question of its potential health benefits and even its use in novel pharmacological approaches. To attain this prospect, some limitations to this molecule, namely its poor bioavailability and solubility, must be addressed. Inflammation and endoplasmic reticulum (ER) stress are often hand in hand in the cont...
Hydrogels and nanostructures formed from ciprofloxacin–peptide conjugates
Jervis, Peter John; Baptista, Inês; Martins, Luciana; Pereira, David M.; Martins, J. A. R.; Ferreira, Paula M. T.Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic that possesses potent activity against both Gram-positive and Gram-negative bacteria and is used to treat many infections. Despite its widespread use, ciprofloxacin is associated with side effects, which might be reduced by improving its pharmacokinetic properties. The chemical structure of ciprofloxacin is the source of some of its limitations, which...
Aryl-capped lysine-dehydroamino acid dipeptide supergelators as potential drug ...
Oliveira, Carlos B. P.; Pereira, Renato B.; Pereira, David M.; Hilliou, L.; Castro, Tarsila Gabriel; Martins, J. A. R.; Jervis, Peter JohnEmploying amino acids and peptides as molecular building blocks provides unique opportunities for generating supramolecular hydrogels, owing to their inherent biological origin, bioactivity, biocompatibility, and biodegradability. However, they can suffer from proteolytic degradation. Short peptides (<8 amino acids) attached to an aromatic capping group are particularly attractive alternatives for minimalistic ...
New 2,6-Bis(5-phenyloxazolyl)pyridine ligands for luminescent LnIII complexes
Carvalho, André; Ferreira, Paula M. T.; Martins, J. A. R.Lanthanide (Ln(III)) luminescent complexes have been attracting interest for technological applications and molecular imaging. The luminescence of Ln(III)) ions is weak and depends on the use of light absorbing coordination ligands which sensitizes the lanthanide ion. A large variety of coordination ligands has been screened such as dipicolinates, oligo-pyridines, cyclen and crown ether derivatives, porphyrins,...
Evaluation of a model photo-caged dehydropeptide as a stimuli-responsive supram...
Jervis, Peter John; Hilliou, L.; Pereira, Renato B.; Pereira, David M.; Martins, J. A. R.; Ferreira, Paula M. T.Short peptides capped on the <i>N</i>-terminus with aromatic groups are often able to form supramolecular hydrogels, via self-assembly, in aqueous media. The rheological properties of these readily tunable hydrogels resemble those of the extracellular matrix (ECM) and therefore have potential for various biological applications, such as tissue engineering, biosensors, 3D bioprinting, drug delivery systems and w...