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Maternal heart exhibits metabolic and redox adaptations post-uncomplicated preg...
Tocantins, Carolina; Martins, João D.; Rodrigues, Óscar M; Grilo, Luís F.; Diniz, Mariana S.; Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, PedroPregnancy may be a challenging period for the maternal systems and has been regarded as a stress test, as imperceptible/mild dysfunctions eventually present may be exacerbated during this period. The cardiovascular system is no exception, and several morphological and functional adaptations accompanying pregnancy have been described. However, long-term pregnancy-induced cardiac molecular alterations remain high...
Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to m...
Pereira, Susana P.; Tavares, Ludgero C.; Duarte, Ana I.; Baldeiras, Inês; Cunha-Oliveira, Teresa; Martins, João D.; Santos, Maria S.; Maloyan, AlinaPoor maternal nutrition in pregnancy affects fetal development, predisposing offspring to cardiometabolic diseases. The role of mitochondria during fetal development on later-life cardiac dysfunction caused by maternal nutrient reduction (MNR) remains unexplored. We hypothesized that MNR during gestation causes fetal cardiac bioenergetic deficits, compromising cardiac mitochondrial metabolism and reserve capaci...
Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondr...
Fernandes, Carlos; Videira, Afonso J. C.; Veloso, Caroline D.; Benfeito, Sofia; Soares, Pedro; Martins, João D.; Gonçalves, Beatriz NunesMitochondriotropic antioxidants (MC3, MC6.2, MC4 and MC7.2) based on dietary antioxidants and analogs (caffeic, hydrocaffeic, trihydroxyphenylpropanoic and trihydroxycinnamic acids) were developed. In this study, we evaluate and compare the cytotoxicity profile of novel mitochondria-targeted molecules (generally known as MitoCINs) on human HepG2 and differentiated SH-SY5Y cells with the quinone-based mitochondr...
Giardia lamblia Decreases NF-κB p65RelA Protein Levels and Modulates LPS-Induce...
Faria, Clarissa Perez; Neves, Bruno Miguel; Lourenço, Ágata; Cruz, Maria Teresa; Martins, João D.; Silva, Ana; Pereira, Sónia; Sousa, Maria do CéuThe protozoan Giardia lamblia is the most common cause of parasitic gastrointestinal infection worldwide. The parasite developed sophisticated, yet not completely disclosed, mechanisms to escape immune system and growth in the intestine. To further understand the interaction of G. lamblia with host immune cells, we investigated the ability of parasites to modulate the canonical activation of mouse macrophages (...
Toxicity assessment of the herbicide metolachlor comparative effects on bacteri...
Pereira, Susana P.; Fernandes, Maria A. S.; Martins, João D.; Santos, Maria S.; Moreno, António J. M.; Vicente, Joaquim A. F.; Videira, Romeu A.Metolachlor is one of the most intensively used chloroacetamide herbicides. However, its effects on the environment and on non-target animals and humans as well as its interference at a cell/molecular level have not yet been fully elucidated. The aim of this study was: firstly, to evaluate the potential toxicity of metolachlor at a cell/subcellular level by using two in vitro biological model systems (a strain ...