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Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc...

Tawfik, Bassam; Martins, Joana S; Houy, Sébastien; Imig, Cordelia; Pinheiro, Paulo S.; Wojcik, Sonja M; Brose, Nils; Cooper, Benjamin H

Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2+-sensors for vesicle fusion in mouse chromaffin cells. When present together, synaptotagmin-1 and synaptotagmin-7 are found in largely non-overlapping clusters on dens...

Date: 2021   |   Origin: Estudo Geral - Universidade de Coimbra
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