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Rewriting Unacceptable Antigens: HLA Delisting to Permit Transplantation - A Cl...
Ribeiro, Lígia; Guerra, Maria Manuel; Silvano, José; Tafulo, Sandra; Martins, La SaleteHighly sensitized kidney transplant candidates experience limited access to compatible donors, prolonged waiting times, and increased mortality while on dialysis due to broad anti-human leukocyte antigen (HLA) antibody reactivity. Advances in immunologic assessment, particularly single-antigen bead assays, have enabled more precise characterization of donor-specific antibodies (DSAs) and facilitated risk-adapte...
Renal artery stenosis in living donor kidney transplantation: a rare cause of “...
Dias, Bruno Fraga; Marques, Roberto; Faria, Vitória; Domingues, Patrícia; Ribeiro, Catarina; Silvano, José; Malheiro, Jorge; Almeida, ManuelaTransplant renal artery stenosis (TRAS) is a well-recognized vascular complication after kidney transplantation, with an incidence ranging from 1% to 23%. TRAS often presents with clinical features such as refractory hypertension, de novo hypertension, allograft dysfunction, and the presence of a bruit over the graft. A rare manifestation of TRAS is flash pulmonary edema. Here, we present a case of a 37-year-ol...
Greater Impact of Living Donation Than HLA Mismatching in Short-Term Renal Allo...
Ribeiro, Bárbara; Reis Pereira, Pedro; Oliveira, João; Almeida, Manuela; Martins, La Salete; J, MalheiroIntroduction: Living donor kidney transplantation (LDKT) is accepted as first-line treatment for patients with end-stage kidney disease with advantages over deceased donor kidney transplantation (DDKT). Still, how the known detrimental effect of HLA mismatch (MM) may hamper these advantages remains unsettled. We sought to determine the effect of the degree of HLA MM, separately in deceased and living donor rena...
Association of the Calcification Score of the Abdominal Aorta, Common Iliac, an...
Ribeiro, Luís Costa; Almeida, Manuela; J, Malheiro; Silva, Filipa; Nunes-Carneiro, Diogo; Martins, La Salete; Pedroso, Sofia; Silva-Ramos, MiguelBackground: Vascular calcification is an ever-more-common finding in protocoled pre-transplant imaging in living kidney donors. We intended to explore whether a connection could be found between the Agatston calcification score, prior to kidney donation, and post-donation renal function. Methods: This is a retrospective analysis of 156 living kidney donors who underwent living donor nephrectomy between January ...
Living Donors’ Age Modifies the Impact of Pre-Donation Estimated Glomerular Fil...
Almeida, Manuela; Ribeiro, Catarina; Silvano, José; Pedroso, Sofia; Tafulo, Sandra; Martins, La Salete; Ramos, Miguel; J, MalheiroBackground: The global scarcity of organs for kidney transplants (KTs) has led to the increased acceptance of living donors (LDs) with minor abnormalities to increase the donor pool.. We sought to evaluate the effects of some of these LDs' clinical characteristics (older age, borderline renal function, hypertension, dyslipidemia, smoking, and obesity) on graft outcomes. Methods: We studied 352 recipients of LDK...
Medical Challenges of a Common Variable Immunodeficiency With a TNFRSF13B Gene ...
Coimbra, Miguel T; Silvano, José; Martins, La SaleteCommon variable immune deficiency (CVID) is a primary immunodeficiency disorder, with hypogammaglobulinemia and increased susceptibility to recurrent infections, autoimmune disorders, granulomatous diseases and malignancy. Among the solid organ transplant (SOT) recipient population, those with primary immunodeficiency disorders under chronic immunosuppression therapy can theoretically be at higher risk of atypi...
CT volumetry performs better than nuclear renography in predicting estimated re...
Almeida, Manuela; Pereira, Pedro R.; Ramos, Miguel; Nunes-Carneiro, Diogo; Mandaleno, Mariana; Silva, Filipa; Pedroso, Sofia; França, ManuelaThe evaluation of split renal function (SRF) is a critical issue in living kidney donations and can be evaluated using nuclear renography (NR) or computerized tomography (CT), with unclear comparative advantages. We conducted this retrospective study in 193 donors to examine the correlation of SRF assessed by NR and CT volumetry and compared their ability to predict remaining donor renal function at 1 year, thr...
Impact of Pancreatic Autoantibodies in Pancreas Graft Survival After Pancreas-K...
Pestana, Nicole; Malheiro, Jorge; Silva, Filipa; Silva, Andreia; Ribeiro, Catarina; Pedroso, Sofia; Almeida, Manuela; Dias, LeonídioIn simultaneous pancreas-kidney transplantation (SPKT), persistence or recurrence of pancreatic autoantibodies (PAs) has been associated with pancreas graft (PG) autoimmune-driven injury. Our aim was to analyze the impact of PAs on PG survival.Methods. Between January 1, 2000, and December 31, 2017, we studied 139 patients with post-SPKT antieglutamic acid decarboxylase (GAD) autoantibody. Alloimmune (ALI) even...
Remaining kidney volume indexed to weight as a strong predictor of estimated gl...
Nunes-Carneiro, Diogo; Madanelo, Mariana; Silva, Filipa; Pestana, Nicole; Ribeiro, Catarina; Gil‐Sousa, Diogo; Martins, La Salete; Almeida, ManuelaThe donors' estimated glomerular filtration rate (eGFR) after living nephrectomy has been a concern, particularly in donors with smaller kindeys. Therefore, we developed this retrospective observational study in 195 donors to determine the ability remaining kidney volume indexed to weight (RKV/W) to predict eGFR at 1 year through multivariate linear regression and to explore this relationship between annual eGF...
The first ABO-incompatible kidney transplantation performed in Portugal
Barreto, Patrícia; Vieira, Pedro; Dias, Leonidio; Almeida, Manuela; Pedroso, Sofia; Martins, La Salete; Henriques, António Castro; BINI ANTUNES, MARIKAKidney transplantation is the optimal treatment of end -stage renal disease (ESRD) improving survival and quality of life for most recipients. In our country, potential living donors have been refused due to the ABO incompatibility barrier. However, ABO -incompatible living donor kidney transplant is presently common practice in several countries with good outcomes. The authors describe a case of a 49 -year -ol...