64 documents found, page 1 of 7

One-Pot Microfluidics to Engineer Chitosan Nanoparticles Conjugated with Antimi...

Surface bioconjugation of antimicrobial peptides (AMP) onto nanoparticles (AMP-NP) is a complex, multistep, and time-consuming task. Herein, a microfluidic system for the one-pot production of AMP-NP was developed. Norbornene-modified chitosan was used for NP production (NorChit-NP), and thiolated-AMP was grafted on their surface via thiol-norbornene "photoclick" chemistry over exposure of two parallel UV LEDs....

Prospective Study of Loss of Health-Related Quality Adjusted Life Years in Chil...

Introduction and aims: Although usually benign, varicella can lead to serious complications and sometimes long-term sequelae. Vaccines are safe and effective but not yet included in immunisation programmes in many countries. We aimed to quantify the impact on health-related quality of life (HRQoL) in terms of quality-adjusted life years (QALY) in children with varicella and their families, key to assessing cost...

Fatores de Risco para Alta Prorrogada por Motivos Sociais: Um Estudo Retrospectivo

Introduction: The hospital setting faces a rate of bed occupation by patients whose discharge is limited by other factors apart from clinical needs. This urges the need for an early identification of the patients at risk of delayed discharge due to social factors in order to reduce expenses and to add value that converts itself into the patient health. The aim of this study was to identify the demographic and c...

A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectua...

Disruptions in the MBD5 gene have been linked with an array of clinical features such as global developmental delay, intellectual disability, autistic-like symptoms, and seizures, through unclear mechanisms. MBD5 haploinsufficiency has been associated with the disruption of primary cilium-related processes during early cortical development, and this has been reported in many neurodevelopmental disorders. In thi...

Oropharyngeal and Laryngeal Manifestations of human Monkeypox

Variabilidade de Apresentação do Tumor de Células Claras: Relato de Casos Clínicos

O cancro afeta signifcativamente a população mundial, tendo sido estimado, em 2018, que o Cancro da Cabeça e Pescoço seria o sétimo mais prevalente. As células claras podem ser resultado de diferentes processos fsiológicos e são encontradas em diversos tumores benignos e malignos. Embora sejam raras nos tumores da cabeça e pescoço, são encontradas maioritariamente nas glândulas salivares. Os tumores de células ...

Experiências Adversas na Infância e Perturbação de Hiperatividade e Défice de A...

A perturbação de hiperatividade e défice de atenção (PHDA) é a perturbação do neurodesenvolvimento mais frequente na faixa etária pediátrica, podendo ter um marcado impacto no funcionamento do indivíduo. Nos últimos anos,tem vindo a ser estudada a associação entre esta patologia e a exposição a adverse childhood experiences (ACEs), i.e.,eventos adversos potencialmente traumáticos vividos antes dos 18 anos. Nest...

Femoral Neuropathy Associated with Prophylactic Anticoagulation in a Patient wi...

Astrocyte structural heterogeneity in the mouse hippocampus

Astrocytes are integral components of brain circuits, where they sense, process, and respond to surrounding activity, maintaining homeostasis and regulating synaptic transmission, the sum of which results in behavior modulation. These interactions are possible due to their complex morphology, composed of a tree-like structure of processes to cover defined territories ramifying in a mesh-like system of fine leaf...

Familial Amyloid Polyneuropathy Misdiagnosed as Systemic Sclerosis

We present the case of a 53-year-old woman of Portuguese ancestry with a diagnosis of progressive systemic sclerosis (SSc), proposed for haematopoietic stem cell transplantation (HSCT). Clinical re-evaluation when assessing eligibility for the procedure led to the alternative diagnosis of familial amyloid polyneuropathy (FAP). We discuss the clinical presentations of FAP and SSc, focusing on their overlapping a...