26 documents found, page 1 of 3
Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic f...
Stevanović-Silva, J; Beleza, J; Coxito, P; Pereira, S; Rocha, H; Gaspar, TB; Gärtner, F; Correia, R; Martins, MJ; Guimarães, T; Martins, S; Oliveira, PJBackground Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development...
Alkaline phosphatase dual-binding sites for collagen dictate cell migration and...
Susana Guerreiro; Unger, RE; Cerqueira, NMFSA; Sartoris, A; Martins, MJ; Barbosa, MA; Soares, R; Granja, PL; Kirkpatrick, CJInteractions between cell types, growth factors, and extracellular matrix components involved in angiogenesis are crucial for new vessel formation leading to tissue regeneration. This study investigated whether cocultures of fibroblasts and endothelial cells (ECs; from macro- or microvasculature) play a role in the formation of microvessel-like structures by ECs, as well as modulate fibroblast differentiation a...
Gut microbiota, in the halfway between nutrition and lung function
Santo, CE; Caseiro, C; Martins, MJ; Monteiro, R; Brandão, IThe gut microbiota is often mentioned as a “forgotten organ” or “metabolic organ”, given its profound impact on host physiology, metabolism, immune function and nutrition. A healthy diet is undoubtedly a major contributor for promoting a “good” microbial community that turns out to be crucial for a fine-tuned symbiotic relationship with the host. Both microbial-derived components and produced metabolites elicit...
Metabolically healthy obesity—Heterogeneity in definitions and unconventional f...
Brandão, I; Martins, MJ; Monteiro, RThe concept of heterogeneity among obese individuals in their risk for developing metabolic dysfunction and associated complications has been recognized for decades. At the origin of the heterogeneity idea is the acknowledgement that individuals with central obesity are more prone to developing type 2 diabetes and cardiovascular disease than those with peripheral obesity. There have been attempts to categorize ...
Differential modulation of cancellous and cortical distal femur by fructose and...
Pereira, C; Guede, D; Durães, C; Brandão, I; Silva, N; Passos, E; Bernardes, M; Monteiro, R; Martins, MJBone mineral density (BMD) and microstructure depend on estrogens and diet. We assessed the impact of natural mineral-rich water ingestion on distal femur of fructose-fed estrogen-deficient female Sprague Dawley rats. Ovariectomized rats drank tap or mineral-rich waters, with or without 10%-fructose, for 10 weeks. A sham-operated group drinking tap water was included (n = 6/group). Cancellous and cortical bone ...
Metabolic syndrome features: Is there a modulation role by mineral water consum...
Costa-Vieira, D; Monteiro, R; Martins, MJMetabolic syndrome (MetSyn) promotes, among others, the development of atherosclerotic cardiovascular disease and diabetes. Its prevalence increases with age, highlighting the relevance of promoting precocious MetSyn primary prevention and treatment with easy-to-implement lifestyle interventions. MetSyn features modulation through mineral water consumption was reviewed on Pubmed, Scopus and Google Scholar datab...
Avaliação do Exame Final do Internato Médico em Portugal
Reis Marques, T; Laíns, I; Martins, MJ; Goiana-da-Silva, F; Sampaio, F; Pessanha, I; Hipólito Fernandes, D; Brandão, M; Pinto Teixeira, PIntrodução: Existe uma elevada heterogeneidade na estrutura da avaliação da formação médica pós-graduada a nível mundial. No entanto, contrastando com outros países, não existem estudos científicos em Portugal que tenham avaliado o modelo da avaliação final da especialidade. O presente estudo pretendeu avaliar a adequação do exame do final da especialidade aos seus propósitos; aí incluída a sua validade enquant...
LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis p...
Bernardes, M; Durães, C; Oliveira, A; Martins, MJ; Lucas, R; Costa, L; Pereira, JG; Ramos, I; Machado, JC; Simões-Ventura, FRheumatoid arthritis (RA) is characterized by increased bone resorption and impaired bone formation. Osteoblast function is regulated by the canonical LRP5/Wnt/-catenin pathway. Bone mineral density and RA joint destruction are partially inherited. In line with this, we found significant associations between LRP5 SNPs (p.A1330V, p.N740N, p.V667M) and RA radiographic damage severity.IntroductionIncreased bone re...
Energy restriction, exercise and atorvastatin treatment improve endothelial dys...
Rocha, B; Rodrigues, AR; Tomada, I; Martins, MJ; Guimarães, J; Gouveia, AM; Almeida, H; Neves, DBackground: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet ...
Autologous fat grafting: Harvesting techniques
Fontes, T; Brandão, I; Negrão, R; Martins, MJ; Monteiro, RAutologous fat grafting is widely used for soft-tissue augmentation and replacement in reconstructive and aesthetic surgery providing a biocompatible, natural and inexpensive method. Multiple approaches have been developed in the past years, varying in the location of adipose tissue donor-sites, use of wetting solutions, harvesting, processing and placing techniques. Despite many advances in this subject, the l...