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Astrocytic signaling supports hippocampal-prefrontal theta synchronization and ...
Sardinha, Vanessa Alexandra Morais; Gomes, Sónia Isabel Nunes Guerra; Campos, Inês Caetano Costa; Tavares, Gabriela Pires; Martins, Manuella MendesAstrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotr...
Employing an open-source tool to assess astrocyte tridimensional structure
Tavares, Gabriela Pires; Martins, Manuella Mendes; Correia, Joana Sofia Silva; Sardinha, Vanessa Alexandra Morais; Gomes, Sónia Isabel Nunes GuerraAstrocytes display important features that allow them to maintain a close dialog with neurons, ultimately impacting brain function. The complex morphological structure of astrocytes is crucial to the role of astrocytes in brain networks. Therefore, assessing morphologic features of astrocytes will help provide insights into their physiological relevance in healthy and pathological conditions. Currently availabl...