3 documents found, page 1 of 1
Pharmacogenetics of advanced lung cancer: Predictive value of functional geneti...
Catarata, Maria Joana; Lourenço, Margarida; Martins, Maria Fátima; Frade, João; Pêgo, Alice; Cordeiro, Carlos Robalo; Medeiros, Rui; Ribeiro, RicardoIntroduction AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome and response to chemotherapy of patients with non-small cell lung cancer (NSCLC) remains to be established. Our aim was to evaluate the association of functional A...
Germline genetic variants of the renin-angiotensin system, hypoxia and angiogen...
Catarata, Maria Joana; Medeiros, Rui; Oliveira, Maria José; Pêgo, Alice; Frade, João Gonçalo; Martins, Maria Fátima; Robalo Cordeiro, Carlos RobaloIntroduction: The renin–angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis. Methods: Geno...
Macroscopic aspects of the anatomy of the reproductive system of escargots: Ach...
Teixeira, Dulcinéa Gonçalves; Guerra, José Luiz; Silva, Zenon; Azarias, Rose Eli Grassi Rici; Martins, Maria FátimaFoi estudada a macro-anatomia do sistema reprodutor do escargot das espécies Achatina fulica e Achatina monochromatica e estabelecidos os parâmetros morfológicos comparativos de ambas espécies. Foram utilizados 15 exemplares de cada espécie com quase 12 meses de idade pertencentes à mesma família. E estes foram sacrificados por congelamento (-2ºC). A coleta do sistema reprodutor foi feita após a retirada da con...