50 documents found, page 1 of 5
Acquired amyloidosis: case report
Antoninho, Rafaela; Carnide, Soraia; Martins, MarianaIntroduction: Familial amyloidotic polyneuropathy (FAP) or amyloidosis is an autosomal dominant disease caused mainly by a mutation in the transthyretin (TTR) gene, leading to the accumulation of amyloid deposits in various tissues and organs, such as the skin, heart, liver, and peripheral nerves. As most plasma TTR is produced by the liver, liver transplantation is the best therapeutic option. The acquired for...
Pharmacological Treatment of Neurogenic Erectile Dysfunction: A Narrative Review
Martins, Mariana; Pereira, Ana; Amaral Silva, Marta; Marques, ElsaErection is a primary event in men’s sexual function, and is particularly valued in this population. Satisfactory sexual function is therefore a key factor for quality of life. Erectile dysfunction is the inability to achieve and/or maintain an erection sufficiently rigid for sexual performance. It may have several aetiologies and is therefore transversal to several medical specialties. Despite being primordial...
Origanum vulgare subsp. virens (Hoffmanns. & Link) Bonnier & Layens Essential O...
Ferreira, Rui; Martins, Mariana; Santos, Vanessa; Sardinha, Duarte; Tavares, Wilson; Sabina, Samuel; Espinel, Guacimara; Barreto, Maria CarmoABSTRACT: Essential oils (EOs) from the leaves of Origanum vulgare subsp. virens (Hoffmanns. & Link) Bonnier & Layens, representing three chemotypes—thymol-rich, carvacrol-rich, and a mixed thymol–carvacrol type—were chemically characterized and comparatively assessed for their antifungal, insecticidal, and enzyme-inhibitory activities. This integrated approach provides a comparative assessment of all three che...
Prevalence of bidirectional intimate partner violence in a sample of college st...
Santiago, João; Martins, Mariana; Cunha, Olga Cecília Soares; Machado, AndreiaPurpose This study aimed to (a) characterize the prevalence of intimate partner violence (IPV) victimization and perpetration; (b) delineate the prevalence and frequency of various types of violence suffered and perpetrated; (c) explore potential gender and sexual orientation differences in the prevalence and frequency of IPV perpetration and victimization; (d) analyze the most common pattern of IPV; and (e) in...
Portuguese visitors’ attitudes towards technology: A segmentation analysis
Martins, Mariana; Rodrigues, VítorNew digital dynamics are being triggered within the tourism ecosystem with direct consequences on visitors’ experiences, which are gradually becoming mediated by emerging and disruptive technologies. However, little is known about visitors’ positioning towards technologies and their impact. This study aims to explore the existence of groups with distinct attitudes towards technology, as well as their characteri...
A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectua...
Martins, Mariana; Oliveira, Ana Rafaela; Martins, Solange; Vieira, José Pedro; Perdigão, Pedro; Fernandes, Ana Rita; Almeida, Luís Pereira deDisruptions in the MBD5 gene have been linked with an array of clinical features such as global developmental delay, intellectual disability, autistic-like symptoms, and seizures, through unclear mechanisms. MBD5 haploinsufficiency has been associated with the disruption of primary cilium-related processes during early cortical development, and this has been reported in many neurodevelopmental disorders. In thi...
Beyond Gonarthrosis in the Elderly: A Case Report of Subchondral Insufficiency ...
Martins, Mariana; Araújo, Raquel; Pinheiro, Rosana; Costa, Ana; Carvalho, José LuísSubchondral insufficiency fracture of the knee (SIFK) is a non-traumatic condition that has been, historically, associated with the elderly. Early diagnosis and management are essential to prevent evolution to subchondral collapse and secondary osteonecrosis, developing prolonged pain and functional losses. This article presents the case of an 83-year-old patient with severe right knee pain with 15 months of ev...
Gestão e Logística da cadeia de abasteciemnto: o caso Grossão S.A
Martins, MarianaA gestão adequada da Cadeia de Abastecimento é fundamental para assegurar a entrega de produtos/serviços ao cliente. Inerente à realização de um estágio curricular na empresa Grossão – Comercio de Bebidas S.A., adiante designada por Grossão, pertencente ao grupo The Fladgate Partnership, o principal objetivo deste estudo é compreender como o processo de compra consegue responder às necessidades do cliente e do ...
The Biology of Lysosomes: From Order to Disorder
Amaral, Olga; Martins, Mariana; Oliveira, Ana Rita; Duarte, Ana Joana; Mondragão-Rodrigues, Inês; Macedo, M. FatimaSince its discovery in 1955, the understanding of the lysosome has continuously increased. Once considered a mere waste removal system, the lysosome is now recognised as a highly crucial cellular component for signalling and energy metabolism. This notable evolution raises the need for a summarized review of the lysosome’s biology. As such, throughout this article, we will be compiling the current knowledge reg...
AD and SDH on Portuguese state-sponsored channels: state of play and where to?
Martins, Cláudia; Xavier, Catarina; Valdez, Susana; Pinto, Sara Ramos; Monteiro, Sílvia Malena; Martins, Mariana; Morgado, MartaThe development of Media Accessibility (MA) has brought to the fore concerns with the inclusion of people with disabilities in all walks of life, from the traditional audiovisual contexts (e.g. TV and cinema) to other cultural and historical venues, including other life events, such as births, weddings, and the like. These concerns stemmed from the fact that, in the 1980s and 1990s, attention was focused on the...