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Strontium ranelate analgesia in arthritis models is associated to decreased cyt...

Nunes, Rodolfo de Melo; Martins, Morgana Ramos; Silva Junior, Francisco Saraiva da; Leite, Ana Caroline Rocha de Melo; Girão, Virgínia Cláudia Carneiro

Objective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. ...

Date: 2016   |   Origin: Oasisbr
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