128 documents found, page 1 of 13
Sex differences in axial spondyloarthritis: data from a Portuguese spondyloarth...
Cunha, RN; Sousa, E; Khmelinskii, N; Ávila, P; Couto, M; Seixas, MI; Martins, N; Bernardes, M; Martins, A; da Silva, AB; Lourenço, MH; Miguel, CBackground: Axial spondyloarthritis (axSpA), particularly ankylosing spondylitis was historically considered a male’s disease and has been under-recognized in women. Emerging evidence reveals sex differences in pathophysiology, disease presentation and therapeutic efficacy. Objective: To identify differences between sexes in a Portuguese cohort of patients with axSpA regarding clinical manifestations, disease a...
Characterization and Evaluation of Layered Bi2WO6 Nanosheets as a New Antibacte...
Leandro, MKDNS; Moura, JVB; Freire, PdTC; Vega, ML; Lima, CdL; Hidalgo, ÁA; Araújo, ACJ; Freitas, PR; Paulo, CLR; Sousa, AK; Rocha, JE; Leandro, LMGBackground: Pathogenic microorganisms are causing increasing cases of mortality and morbidity, along with alarming rates of ineffectiveness as a result of acquired antimicrobial resistance. Bi2WO6 showed good potential to be used as an antibacterial substance when exposed to visible light. This study demonstrates for the first time the dimension-dependent antibacterial activity of layered Bi2WO6 nanosheets. Mat...
Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials
Das, G; Shin, HS; Leyva-Gómez, G; Prado-Audelo, MLD; Cortes, H; Singh, YD; Panda, MK; Mishra, AP; Nigam, M; Saklani, S; Chaturi, PK; Martorell, MIn recent decades, interest in the Cordyceps genus has amplified due to its immunostimulatory potential. Cordyceps species, its extracts, and bioactive constituents have been related with cytokine production such as interleukin (IL)-1ß, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-a, phagocytosis stimulation of immune cells, nitric oxide production by increasing inducible nitric oxide synthas...
Conifers phytochemicals: A valuable forest with therapeutic potential
Bhardwaj, K; Silva, AS; Atanassova, M; Sharma, R; Nepovimova, E; Musilek, K; Sharma, R; Alghuthaymi, MA; Dhanjal, DS; Nicoletti, M; Sharma, BConifers have long been recognized for their therapeutic potential in different disorders. Alkaloids, terpenes and polyphenols are the most abundant naturally occurring phytochemicals in these plants. Here, we provide an overview of the phytochemistry and related commercial products obtained from conifers. The pharmacological actions of different phytochemicals present in conifers against bacterial and fungal i...
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: E...
Taheri, Y; Sharifi-Rad, J; Antika, G; Yilmaz, YB; Tumer, TB; Abuhamdah, S; Chandra, S; Saklani, S; Kiliç, CS; Sestito, S; Dastan, SD; Kumar, MLuteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, a...
Nanotechnology-Based Strategies for Berberine Delivery System in Cancer Treatme...
Iqbal, MJ; Quispe, C; Javed, Z; Sadia, H; Qadri, QR; Raza, S; Salehi, B; Martins, N; Abdulwanis Mohamed, Z; Sani Jaafaru, M; Abdull Razis, AFCancer is a multifactorial disease characterized by complex molecular landscape and altered cell pathways that results in an abnormal cell growth. Natural compounds are target-specific and pose a limited cytotoxicity; therefore, can aid in the development of new therapeutic interventions for the treatment of this versatile disease. Berberine is a member of the protoberberine alkaloids family, mainly present in ...
Pleiotropic Effects of Tetracyclines in the Management of COVID-19: Emerging Pe...
Al-kuraishy, HM; Al-Gareeb, AI; Alqarni, M; Martins, N; El-Saber Batiha, GCoronavirus disease 2019 (COVID-19) is a global infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Approximately 15% of severe cases require an intensive care unit (ICU) admission and mechanical ventilation due to development of acute respiratory distress syndrome (ARDS). Tetracyclines (TCs) are a group of bacteriostatic antibiotics, like tetracycline, minocycline, and do...
Green Synthesized Silver Nanoparticles as Potent Antifungal Agent against Asper...
Anum, F; Jabeen, K; Javad, S; Iqbal, S; Tahir, A; Javed, Z; Martins, N; Ayatollahi, SA; Sharifi-Rad, J; Alshehri, MM; Cho, WCMedicinal plants are composed of a rich pool of biomolecules and have been increasingly recognized for their antimicrobial properties; however, increasing concerns have been put on the bioavailability features. Thus, this study is aimed at exploring the synthesis and characterization of silver nanoparticles synthesized by Chenopodium album L. leaf extract and assessing the antifungal activity against Aspergillu...
Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
Ramírez-Alarcón, K; Victoriano, M; Mardones, L; Villagran, M; Al-Harrasi, A; Al-Rawahi, A; Martins, N; Sharifi-Rad, J; Martorell, MType 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired ß-pancreatic cell function and insulin secretion, hyperglycemia and insulin resistance, and recently the epigenetic regulation of ß-pancreat...
Case Report: Hyperbilirubinemia in Gilbert Syndrome Attenuates Covid-19-Induced...
Al-kuraishy, HM; Al-Gareeb, AI; Abdullah, SM; Martins, N; Batiha, GESGilbert syndrome (GS) is a liver disorder characterized by non-hemolytic unconjugated hyperbilirubinemia. On the other hand, Coronavirus disease 2019 (Covid-19) is a recent viral infectious disease presented as clusters of pneumonia, triggered by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Little is known on the association between SARS-CoV-2 and GS, despite different studies have recently...