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Ferritin heavy chain supports stability and function of the regulatory T cell l...
Wu, Qian; Carlos, Ana Rita; Braza, Faouzi; Bergman, Marie-Louise; Kitoko, Jamil Z; Bastos-Amador, Patricia; Cuadrado, Eloy; Martins, RuiRegulatory T (TREG) cells develop via a program orchestrated by the transcription factor forkhead box protein P3 (FOXP3). Maintenance of the TREG cell lineage relies on sustained FOXP3 transcription via a mechanism involving demethylation of cytosine-phosphate-guanine (CpG)-rich elements at conserved non-coding sequences (CNS) in the FOXP3 locus. This cytosine demethylation is catalyzed by the ten–eleven transl...
Maternal dietary exposure to mycotoxin aflatoxin B1 promotes intestinal immune ...
Bastos-Amador, Patricia; Duarte, Elsa Leclerc; Torres, Júlio; Caldeira, Ana Teresa; Silva, Inês; Salvador, Cátia; Assunção, Ricardo Edgar MoreiraMycotoxins are secondary metabolites produced by fungi occurring in food that are toxic to animals and humans. Early-life mycotoxins exposure has been linked to diverse pathologies. However, how maternal exposure to mycotoxins impacts on the intestinal barrier function of progeny has not been explored. Here, exposure of pregnant and lactating C57Bl/6J female mice to aflatoxin B1 (AFB1; 400 μg/kg body weight/day...
Maternal dietary exposure to mycotoxin aflatoxin B1 promotes intestinal immune ...
Bastos-Amador, Patricia; Duarte, Elsa Leclerc; Torres, Júlio; Caldeira, Ana Teresa; Silva, Inês; Salvador, Cátia; Assunção, Ricardo; Alvito, PaulaAbstract: Mycotoxins are secondary metabolites produced by fungi occurring in food that are toxic to animals and humans. Early-life mycotoxins exposure has been linked to diverse pathologies. However, how maternal exposure to mycotoxins impacts on the intestinal barrier function of progeny has not been explored. Here, exposure of pregnant and lactating C57Bl/6J female mice to aflatoxin B1 (AFB1; 400 μg/kg body ...
Exposição precoce a micotoxinas: o contributo dos projetos MYCOMIX e earlyMYCO
Alvito, Paula; Bastos-Amador, Patricia; Duarte, Elsa L.; Ferreira, Manuela; Nunes, Carla; Martins, Carla; Assunção, RicardoA exposição a contaminantes químicos nos primeiros 1000 dias de vida tem sido associada a alterações de saúde, constituindo um domínio emergente de pesquisa fundamental para o conhecimento do exposoma humano. As micotoxinas produzidas por fungos integram a lista de contaminantes químicos tóxicos presentes nos alimentos e têm efeitos carcinogénicos, nefrotóxicos, hepatotóxicos e imunossupressores. A mucosa intes...