13 documents found, page 1 of 2
De novo and inherited dominant variants in U4 and U6 snRNA genes cause retiniti...
Quinodoz, Mathieu; Rodenburg, Kim; Cvackova, Zuzana; Kaminska, Karolina; de Bruijn, Suzanne E.; Iglesias-Romero, Ana Belén; Boonen, Erica G.M.Small nuclear RNAs (snRNAs) combine with specific proteins to generate small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. U4 snRNA forms a duplex with U6 and, together with U5, contributes to the tri-snRNP spliceosomal complex. Variants in RNU4-2, which encodes U4, have recently been implicated in neurodevelopmental disorders. Here we show that heterozygous inherited and de novo ...
Investigating the evolution of Drosophila STING-dependent antiviral innate immu...
Hédelin, Léna; Thiébaut, Antonin; Huang, Jingxian; Li, Xiaoyan; Lemoine, Aurélie; Haas, Gabrielle; Meignin, Carine; Cai, Hua; Waterhouse, Robert M.Viruses represent a major threat to all animals, which defend themselves through induction of a large set of virus- stimulated genes that collectively control the infection. In vertebrates, these genes include interferons that play a critical role in the amplification of the response to infection. Virus- and interferon-stimulated genes include restriction factors targeting the different steps of the viral repli...
Evolutionary immunology to explore original antiviral strategies
Imler, Jean-Luc; Cai, Hua; Meignin, Carine; Martins, NelsonOver the past 25 years, the field of evolutionary developmental biology (evo-devo) has used genomics and genetics to gain insight on the developmental mechanisms underlying the evolution of morphological diversity of animals. Evo-devo exploits the key insight that conserved toolkits of development (e.g., Hox genes) are used in animals to produce genetic novelties that provide adaptation to a new environment. Li...
Embedded model predictive control of tankless gas water heaters to enhance user...
Conceição, Cheila; Quintã, André; Ferreira, Jorge A. F.; Martins, Nelson; Santos, Marco P. Soares dosWater heating is a significant part of households’ energy consumption, and tankless gas water heaters (TGWHs) are commonly used. One of the limitations of these devices is the difficulty of keeping hot water temperature setpoints when changes in water flow occur. As these changes are usually unexpected, the controllers typically used in these devices cannot anticipate them, strongly affecting the users’ comfort...
Code generation for embedded predictive control of gas water heaters
Quintã, André; Conceição, Cheila; Martins, Nelson; A. F. Ferreira, JorgeConventional control strategies usually employed in tankless gas water heaters present difficulty in controlling the hot water temperature when subjected to sudden changes in water flow rate. Inadequate control leads to temperature overshoots and undershoots with long settling times that severely affect the user comfort, increasing water and energy wastage and associated gas emissions. A strategy based on model...
Gain scheduling model predictive controller design for tankless gas water heate...
Quintã, André F.; Ehtiwesh, Ismael; Martins, Nelson; Ferreira, Jorge A. F.One of the most significant drawbacks of tankless gas water heaters is the difficulty of controlling the outlet hot water temperature as changes in water demand cannot be predicted. These sudden changes in hot water flow rate, are associated with the system inhered delays, and are responsible for temperature overshoots and undershoots that severely affect the comfort perception of the user. In the present work,...
Experimental and computational analysis of NOx photocatalytic abatement using c...
Zhiltsova, Tatiana; Martins, Nelson; Silva, Mariana R. F.; Silva, Carla F. da; Lourenço, Mirtha A. O.; Tobaldi, David M.; Covita, DanielIn the present study, two photocatalytic graphene oxide (GO) and carbon nanotubes (CNT) modified TiO2 materials thermally treated at 300 C (T300_GO and T300_CNT, respectively) were tested and revealed their conversion e ciency of nitrogen oxides (NOx) under simulated solar light, showing slightly better results when compared with the commercial Degussa P25 material at the initial concentration ofNOx of 200 ppb....
The Circular Economy as a promoter of sustainability
Martins, Nelson; Afgan, Naim; Borrego, Carlos; Ferreira Dias, Marta; Nunes, Maria Isabel; Felgueiras, Carlos; Caetano, Nídia(Excerpt) A circular economy encourages sustainability and competitiveness in the long term. The recognized scarcity of key natural resources and the growing volume of industrial and urban waste are the basis of the recognition that a circular economy approach is the pathway for sustainable development. On 4th March 2019, the European Commission adopted a comprehensive report on the implementation of a Circular...
The potential of energy behaviours in a smart(er) grid: Policy implications fro...
Lopes, Marta A.R.; Antunes, Carlos Henggeler; Janda, Kathryn B.; Peixoto, Paulo; Martins, NelsonThe transition to smart grids is an on-going process that may both shape and be shaped by end-users' energy behavioural adaptations. This study explores current and potential energy behavioural adaptations in Portugal during the smart grid transition process. A web-based survey was made to a representative sample of a specific segment of Portuguese residential end-users. The survey evaluated current energy beha...
Testing hypotheses on the resistance to metals by Daphnia longispina: different...
Saro, Liliana; Lopes, Isabel; Martins, Nelson; Ribeiro, RuiPollution by metals may lead to an increased tolerance in the exposed population through adaptive microevolution, with resistant genotypes becoming more abundant than in reference sites. This work investigated the outcomes associated with selection for resistance by testing three hypotheses to assess the following: Do resistant versus sensitive clonal lineages of Daphnia longispina differentially acclimate to m...