95 documents found, page 1 of 10
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-v...
Reina-Couto, M; Alves, D; Silva-Pereira, C; Pereira-Terra, P; Martins, S; Bessa, J; Teixeira-Santos, L; Pinho, D; Morato, M; Dias, CC; Sarmento, A"Background and aims: Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane oxygenation (VV-ECMO), hypertension or previous renin-angiotensin-aldosterone system (RAAS) inhibitors treatment. We compared endocan and other endotheliitis markers in hospitalized COVID-19 patients and assessed their modulation by VV-ECMO, hypertension and previous R...
Estimated dietary flavonoid intake and major food contributors in the Portugues...
Martins, S; Meireles, M; Caetano, E; Correia, D; Carvalho, C; Silva, CC; Magalhaes, V; Vilela, S; Lopes, C; Torres, DuarteFlavonoids are a key class of polyphenols, i.e., phytochemical compounds present in foods and beverages, which have been described as having health benefits in preventing several chronic diseases. Estimating flavonoid intake has already been conducted in several countries but has yet to be performed in Portugal. This study included 5005 participants aged 3-84 years and aimed to estimate dietary flavonoid intake...
Estimated dietary flavonoid intake and major food contributors in the Portugues...
Martins, S; Meireles, M; Caetano, E; Correia, D; Carvalho, C; Campos Silva, C; Magalhães, V; Vilela, S; Lopes, C; Torres, DFlavonoids are a key class of polyphenols, i.e., phytochemical compounds present in foods and beverages, which have been described as having health benefits in preventing several chronic diseases. Estimating flavonoid intake has already been conducted in several countries but has yet to be performed in Portugal. This study included 5,005 participants aged 3-84 years and aimed to estimate dietary flavonoid intak...
Total neoadjuvant therapy: A new standard of care for locally advanced rectal c...
Leite, J; Martins, SDelivering chemotherapy before surgery is a newer treatment approach called total neoadjuvant therapy (TNT), and the National Comprehensive Cancer Network guidelines recommend it for locally advanced rectal cancer (LARC) with cT3 / cN+ / cT4, in contrast with the European Society for Medical Oncology guidelines, in which most rectal cancers can be treated with surgery alone if good quality mesorectal resection ...
Impact of a daily legume-based meal on blood and anthropometric parameters in a...
Ferreira, H; Vasconcelos, M; Gil, AM; Silveira, J; Alves, P; Martins, S; Assunção, M; Guimarães, JT; Pinto, EThis pilot study aimed to assess the impact of substituting a traditional lunch for a vegetarian legume-based meal on blood and anthropometric parameters in a group of omnivorous adults. A one-group comparison, quasi-experimental dietary intervention was designed. A vegetarian legume-based meal was offered for 8 consecutive weeks (weekdays) to non-vegetarian individuals (n = 26), (28 years [P25 = 20.0, P75 = 35...
Evaluation of SARS-CoV-2 interferon gamma release assay in BNT162b2 vaccinated ...
Ramos, A; Martins, S; Marinho, AS; Norton, P; Cardoso, MJ; Guimarães, JTTo predict protective immunity to SARS-CoV-2, cellular immunity seems to be more sensitive than humoral immunity. Through an Interferon-Gamma (IFN-γ) Release Assay (IGRA), we show that, despite a marked decrease in total antibodies, 94.3% of 123 healthcare workers have a positive cellular response 6 months after inoculation with the 2nd dose of BNT162b2 vaccine. Despite the qualitative relationship found, we di...
Feasibility and Effectiveness of a 12-Week Concurrent Exercise Training on Phys...
Barros, D; Silva-Fernandes, A; Martins, S; Guerreiro, S; Magalhães, J; Carvalho, J; Marques, EA"Objective To examine the feasibility and effects of a 12-week exercise intervention on physical performance, muscular strength, and circulating myokines in frail individuals living in nursing homes. Design A cluster randomized, 2-period, 2-intervention crossover trial. Setting and Participants Frail residents of 9 nursing homes were randomly assigned to either 12 weeks of concurrent exercise training (n = 5, 2...
A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectua...
Martins, M; Oliveira, AR; Martins, S; Vieira, JP; Perdigão, P; Fernandes, AR; de Almeida, LP; Palma, PJ; Sequeira, DB; Santos, JM; Duque, F; Oliveira, GDisruptions in the MBD5 gene have been linked with an array of clinical features such as global developmental delay, intellectual disability, autistic-like symptoms, and seizures, through unclear mechanisms. MBD5 haploinsufficiency has been associated with the disruption of primary cilium-related processes during early cortical development, and this has been reported in many neurodevelopmental disorders. In thi...
The pro-resolving lipid mediator Maresin 1 ameliorates pain responses and neuro...
Teixeira-Santos, L; Martins, S; Sousa, T; Albino-Teixeira, A; Pinho, DSpecialized pro-resolving mediators (SPMs) have recently emerged as promising therapeutic approaches for neuropathic pain (NP). We evaluated the effects of oral treatment with the SPM Maresin 1 (MaR1) on behavioral pain responses and spinal neuroinflammation in male and female C57BL/6J mice with spared nerve injury (SNI)-induced NP. MaR1, or vehicle, was administered once daily, on post-surgical days 3 to 5, by...
Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and puta...
Reina-Couto, M; Roboredo-Madeira, M; Pereira-Terra, P; Silva-Pereira, C; Martins, S; Teixeira-Santos, L; Pinho, D; Dias, A; Cordeiro, G; Dias, CCBackground Cysteinyl leukotrienes (CysLT) are potent inflammation-promoting mediators, but remain scarcely explored in COVID-19. We evaluated urinary CysLT (U-CysLT) relationship with disease severity and their usefulness for prognostication in hospitalized COVID-19 patients. The impact on U-CysLT of veno-venous extracorporeal membrane oxygenation (VV-ECMO) and of comorbidities such as hypertension and obesity ...