11 documents found, page 1 of 2

Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolacton...

Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans. The tissue damage characteristic of BU lesions is known to be driven by the secretion of the potent lipidic exotoxin mycolactone. However, the molecular action of mycolactone on host cell biology mediating cytopathogenesis is not fully understood. Here we applied two-dimensional electrophoresis (2-DE) to identify the mechanisms ...

Phage therapy is effective against infection by Mycobacterium ulcerans in a mur...

Author Summary: Buruli Ulcer (BU), caused by Mycobacterium ulcerans, is a necrotizing disease of the skin, subcutaneous tissue and bone. Standard treatment of BU patients consists of a combination of the antibiotics rifampicin and streptomycin for 8 weeks. However, in advanced stages of the disease, surgical resection of the destroyed skin is still required. The use of bacterial viruses (bacteriophages) for the...

Innovative anti-microbial strategies against buruli ulcer : bacteriophage therapy

Local and regional re-establishment of cellular immunity during curative antibi...

BACKGROUND: Buruli ulcer (BU) is a neglected necrotizing disease of the skin, subcutaneous tissue and bone, caused by Mycobacterium ulcerans. BU pathogenesis is associated with mycolactone, a lipidic exotoxin with cytotoxic and immunosuppressive properties. Since 2004, the World Health Organization recommends the treatment of BU with a combination of rifampicin and streptomycin (RS). Histological analysis of hu...

Experimental phage therapy against Mycobacterium ulcerans in mice model

Host-pathogen interactions in Mycobacterium ulcerans infections: implications f...

Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), a necrotizing disease of the skin, subcutaneous tissue and bone. BU pathogenesis is associated with mycolactone, a lipidic exotoxin with cytotoxic and immunosuppressive properties. The treatment of BU consists of a combination of rifampicin and streptomycin (RS), with successful results for nonulcerative and small ulcers, but variation in effic...

Cellular immunity confers transient protection in experimental buruli ulcer fol...

BACKGROUND: Buruli ulcer (BU) is an emerging infectious disease caused by Mycobacterium ulcerans that can result in extensive necrotizing cutaneous lesions due to the cytotoxic exotoxin mycolactone. There is no specific vaccine against BU but reports show some degree of cross-reactive protection conferred by M. bovis BCG immunization. Alternatively, an M. ulcerans-specific immunization could be a better prevent...

Corticosteroid-Induced Immunosuppression ultimately does not compromise the eff...

Buruli ulcer (BU) is a necrotizing disease of the skin, subcutaneous tissue and bone caused by Mycobacterium ulcerans. It has been suggested that the immune response developed during the recommended rifampicin/streptomycin (RS) antibiotherapy is protective, contributing to bacterial clearance. On the other hand, paradoxical reactions have been described during or after antibiotherapy, characterized by pathologi...

Mycobacterium ulcerans Triggers T-cell immunity followed by local and regional ...

Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-...

Dextrin nanoparticles: studies on the interaction with murine macrophages and b...

The uptake of nanoparticles by cells of the mononuclear phagocytic system limits its use as colloidal drug carriers, reducing the blood circulation time and the ability to reach biological targets. In this work, the interaction between dextrin nanoparticles – recently developed in our laboratory – and murine bone marrow-derived macrophages was evaluated. Cytotoxicity and nitric oxide production were studied, us...