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A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively dru...
Campos, Tatiana Amabile de; Gonçalves, Laura Fernandes; Magalhães, Kelly Grace; Martins, Vicente de Paulo; Pappas Júnior, Georgios JoannisWe report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not p...
Comparative genomics of the major fungal agents of human and animal Sporotricho...
Teixeira, Marcus de Melo; Almeida, Luiz G. P. de; Barreira, Paula Kubitschek; Alves, Fernanda L.; Kioshima, Érika Seki; Abadio, Ana Karina RodriguesBackground: The fungal genus Sporothrix includes at least four human pathogenic species. One of these species, S. brasiliensis, is the causal agent of a major ongoing zoonotic outbreak of sporotrichosis in Brazil. Elsewhere, sapronoses are caused by S. schenckii and S. globosa. The major aims on this comparative genomic study are: 1) to explore the presence of virulence factors in S. schenckii and S. brasiliens...
Vaccination with enzimatically cleaved GPI-anchored proteins from Schistosoma m...
Martins, Vicente de Paulo; Pinheiro, Carina da Silva; Figueiredo, Bárbara de Castro Pimentel; Assis, Natan Raimundo Gonçalves deThe flatworm Schistosoma mansoni is a blood fluke parasite that causes schistosomiasis, a debilitating disease that occurs throughout the developing world. Current schistosomiasis control strategies are mainly based on chemotherapy, but many researchers believe that the best long-termstrategy to control schistosomiasis is through immunization with an antischistosomiasis vaccine combined with drug treatment. In ...