28 documents found, page 1 of 3
Histological analysis of the intestinal wall of newborn rats submitted to hypox...
Silvares,Soraia Guerra; Moron,Antonio Fernandes; Simões,Manuel de Jesus; Cintra,Álvaro Ulhoa; Montero,Edna Frasson de Souza; Araujo Júnior,EdwardAbstract Purpose To evaluate the effect of N-Acetylcysteine (NAC) in newborn rats submitted to hypoxia and reoxygenation (H/R) conditions in an experimental model of necrotizing enterocolitis. Methods Eight pregnant rats and their 70 cubs were used (5 groups) and exposed to H/R conditions and received NAC at different times. The animals in the H/R groups were placed in a gas chamber (100% CO2) for 10 minutes an...
Oxidative stress assessment in intestine of newborn rats submitted to hypoxia a...
Teixeira,Luciana Cristina; Fujiki,Renato Toshio Murashita; Souza,Caio Vinicius Coitinho Paiva de; Souza,Camila Mendes de; Mismetti,Maysa MoreiraAbstract Purpose: To evaluate the functional and structural response of tadalafil effects in the intestinal mucosa, using an experimental model of hypoxia and reoxygenation injury in rats. Methods: The animals were divided into 4 groups: CTL, H/R, H/R+Td and M+Td. The newborn rats allocated in groups H/R, H/R+Td and M+Td were submitted twice a day, to a gas chamber with CO2 at 100% for 10 minutes and afterward ...
Neonatal necrotizing enterocolitis rat model attenuated by a remote ischemic pr...
Gomes,Rúdnei de Oliveira Luciano; Artigiani Neto,Ricardo; Guimarães Neto,José de Freitas; Nunes,Adriana Porto; Montero,Edna Frasson de SouzaAbstract Purpose: To evaluate the effect of remote ischemic preconditioning (r-IPC) administered to pregnant rats, in the ileum of newborn rats subjected to hypoxia and reoxygenation. Methods: We used three pregnant rats and their newborn rats distributed in three groups: 1) Control (C) - Newborn rats born from a pregnant rat which did not undergo any intervention; 2) Hypoxia-Reoxygenation (H/R) - Newborn rats ...
Effect of atenolol pre-treatment in heart damage in a model of intestinal ische...
Okada,Mieko; Falcão,Luiz Fernando Reis; Ferez,David; Martins,José Luiz; Errante,Paolo Ruggero; Rodrigues,Francisco Sandro Menezes; Caricati-Neto,AfonsoAbstract Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and o...
Effect of folic acid in a modified experimental model of anorectal malformation...
Faria,Danilo José Fiorindo; Simões,Manuel de Jesus; Teixeira,Luciana Cristina; Faria,Angela Tucci Pinheiro; Cintra,Álvaro Edmundo Simões UlhoaPURPOSE: To determine the effect of a single dose of adriamycin (ADR) to induce anorectal malformations (ARMs) and determine the effect of folic acid (FA) in this model. METHODS: Ten female Wistar rats were divided randomly in two groups. Group A - ADR; Group B - FA+ADR. Dams from group B received daily, since two weeks before the pregnancy to the end of pregnancy, FA (50mg/kg) by gavage. Dams from both groups ...
Is it possible folic acid reduce anorectal malformations ethylenethiourea induc...
Faria,Danilo José Fiorindo; Simões,Manuel de Jesus; Martins,José LuizPURPOSE: To investigate the effect of folic acid (FA) in an experimental model of anorectal malformations (ARMs) ethylenethiourea (ETU) induced.METHODS:Eight female Wistar rats were divided randomly in two groups. Group A - ETU; Group B - FA+ETU; Dams from group B received daily, since two weeks before pregnancy to the end of pregnancy, FA (50mg/kg) by gavage. Dams from groups A and B, received 1% ETU (125mk/kg...
The effect of simvastatin on the regeneration of surgical cavities in the femur...
Rosselli,José Eduardo Gomes Cardim; Martins,Dulce Maria Fonseca Soares; Martins,José Luiz; Oliveira,Claudia Regina Gomes Cardim Mendes dePURPOSE:To evaluate the effect of a local application of simvastatin gel in repairing bone defects in the femurs of rabbits.METHODS:Two standard surgical cavities were created in the femoral epiphysis of 18 rabbits. In the simvastatin group (SG), the cavities were filled with a collagen sponge soaked in 0.5 ml of a simvastatin (1 mg) gel, and the cavities were covered with a biological membrane. The bone caviti...
Effects of maternal ischemic preconditioning in the colon of newborn rats submi...
Freitas,Maria Andréia Lopes de; Gomes,Rúdnei de Oliveira Luciano; Soares,Bruno Leonardo de Freitas; Artigiani Neto,RicardoPURPOSE: To evaluate the effects of maternal remote ischemic preconditioning (IPCr) in the colonic mucosa of newborn rats subjected to hypoxia and reoxygenation.METHODS:Newborn Wistar rats were divided into three groups. Control Group (CG), Hypoxia and Reoxygenation Group (HRG) and Remote Ischemic Preconditioning Group (IPCrG). Hypoxia and reoxygenation was performed 2x per day, with an interval of 6 hours, on ...
Hepatic damage in newborns from female rats exposed to the pesticide derivative...
Lemos,Patrícia Veruska Ribeiro Barbosa; Martins,José Luiz; Lemos,Sidney Pereira Pinto; Santos,Fernando Leandro dos; Silva,Sílvio Romero Gonçalves ePURPOSE: To evaluate hepatic morphological-histological abnormalities in newborns from female rats exposed to ethylenethiourea. METHODS: A randomized study was conducted on fifty-five newborn Wistar rats were studied: 34 in the experimental group, whose mothers had been exposed to 1% ethylenethiourea; and 21 in the control group, whose mothers had received 0.9% physiological solution. The solution was administe...
Abnormalities of digestive tract innervation in rat fetus treated with ethylene...
Lemos,Sidney Pereira Pinto; Martins,José Luiz; Lemos,Patrícia Veruska Ribeiro Barbosa; Silva,Silvio Romero Gonçalves e; Santos,Fernando Leandro dosPURPOSE: The pathophysiology of abnormalities associated with myenteric plexus lesions remains imperfectly understood. Such abnormalities have been correlated with subocclusive intestinal conditions in children with Hirschsprung's disease, cases of chronic constipation and, postoperatively, in cases of anorectal anomalies. This study evaluated abnormalities of the myenteric plexus in fetus from female rats that...