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Unlocking the functional potential of Mesembryanthemum nodiflorum: Insights int...
Pinto, Diana; Vieira, Raquel; Teixeira, Filipa; Sut, Stefania; Vieira, Mónica; Salazar, Miguel; Delerue-Matos, Cristina; Dall’Acqua, StefanoMesembryanthemum nodiflorum, commonly known as slenderleaf iceplant, is an undervalued edible halophyte. The nutraceutical potential of M. nodiflorum was investigated in the current study by extracting bioactive compounds using ultrasound-assisted extraction (UAE) and assessing the influence of gastrointestinal digestion and intestinal permeability on their bioactive composition. The phenolic and flavonoid cont...
Optimized extraction protocols for bioactive antioxidants from commercial seawe...
Santos, Francisca; Soares, Cristina; Morais, Stephanie L.; Neves, Cátia; Grosso, Clara; Ramalhosa, Maria João; Vieira, Mónica; Delerue-Matos, CristinaThis study aimed to optimize the extraction conditions for a valuable source of antioxidants: seaweed. Therefore, ten seaweed samples were subjected to a solid–liquid extraction (SLE), where the extraction conditions (biomass (g): solvent (mL) ratio, temperature, and time) were optimized using response surface methodology (RSM). The seaweeds were also subjected to subcritical water extraction (SWE) (140 and 190...
Development of an in vitro skin cell model and comparison with ex vivo models: ...
Marques, Mariana; Teixeira, Filipa; Vieira, Mónica; Rodrigues, Francisca; Vieira, MónicaSkin is the first physical barrier against pathogens and mechanical injuries, and stratum corneum, the outermost layer of the skin, is the primary barrier to therapeutic delivery. Skin is divided into the epidermis, which consists mainly of keratinocytes and the dermis, composed of fibroblasts, and extracellular matrix components. Skin models are crucial for assessing the safety and efficacy of cosmetic ingredi...
Betulinic acid and obesity-related disorders
Azevedo, Lara; Ferraz, Ricardo; Vieira, Mónica; Prudêncio, Cristina; Fernandes, Sílvia; Ferraz, Ricardo; Almeida Vieira, Mónica AndreiaThe obesity epidemic is not just a health issue, it is increasingly driving a shift in the prevalence of chronic diseases, affecting 890 million adults and straining healthcare systems worldwide. Conditions such as type 2 diabetes mellitus, cardiovascular diseases, non-alcoholic fatty liver disease, and various cancer types are closely tied to this growing crisis. Betulinic acid has anti-inflammatory, antioxida...
Unraveling the nutraceutical potential of Salicornia ramosissima by-product – i...
Pinto, Diana; Santos, Inês; Delerue-Matos, Cristina; Teixeira, Filipa; Sut, Stefania; Dall’Acqua, Stefano; Vieira, Mónica; Rodrigues, FranciscaSalicornia ramosissima by-product (SP) is an underexploited antioxidant-rich by-product. This study explored the phytochemical profile, bioaccessibility, and biological activity of SP before and after extraction (SBE and SAE, respectively) upon gastrointestinal simulated digestion and intestinal permeability. The phenolic and flavonoid concentrations increased during digestion, reaching bioaccessibility rates a...
Nature-based hydrogels combined with nanoparticles for bone regeneration
Fernandes, Margarida; Vieira, Mónica; Peixoto, Daniela; Alves, Natália M.; Vieira, MónicaBone is a calcified tissue composed of 60% inorganic compounds, 30% organic compounds, and 10% water. Bone exhibits an intrinsic regenerative capacity, enabling it to heal after fractures or adapt during growth. However, in cases of severe injury or extensive tissue loss, this regenerative capacity becomes insufficient, often necessitating bone graft surgeries using autografts or allografts. Conventional grafti...
A practical case of mentoring in higher education at a health school
Saúde, Miguel; Ferraz, Ricardo; Silva, Vítor; Barreto, João; Portugal, Paula; Santos, Joana; Vieira, Mónica; Vieira, Mónica; Santos, JoanaThe rapid advancement of Generative Artificial Intelligence (AI) tools is reshaping higher education, particularly in creative fields such as design, multimedia, and audiovisuals. Students increasingly seek faster solutions for academic challenges, often relying on AI-generated content rather than engaging in research, critical analysis, and validation through credible sources or instructors. This tendency weak...
Exploring treatment strategies for paroxysmal nocturnal hemoglobinuria: an over...
Peixoto, Vanda; Prudêncio, Cristina; Vieira, MónicaParoxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease in which blood cells lack anchored proteins that regulate the complement system. The erythrocytes are then destroyed because of uncontrolled complement activity, leading to intravascular hemolysis (IVH) and a high risk of thrombosis outcome. A huge alteration in the treatment of the disease was the development of terminal complement inhibitor...
From the gut to the brain: Is microbiota a new paradigm in Parkinson’s disease ...
Vilela, Cristiana; Araújo, Bruna; Guedes, Carla; Silva, Rita Caridade; Macedo, Joana Martins; Teixeira, Catarina; Gomes, Eduardo; Prudêncio, CristinaParkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of the central nervous system. Clinically, PD is characterized as a movement disorder, exhibiting an incidence and mortality rate that is increasing faster than any other neurological condition. In recent years, there has been a growing interest concerning the role of the gut microbiota in the etiology...
Goji berries (Lycium barbarum) extract as new potential cosmetic ingredient – A...
Silva, Joana; Teixeira, Filipa; Silva, Ana M.; Vieira, Mónica; Amaral, M. Helena; Rodrigues, Francisca; Vieira, MónicaCurrently there is greater concern about appearance and skin care products. Although cosmetic products are not associated with serious health problems, there are concerns related to undesirable effects due to the presence of potentially carcinogenic and allergenic ingredients. Thus, consumers have been increasingly looking for products of natural and plant-based origin. The use of these products is expected to ...