6 documents found, page 1 of 1
Influência do sexo na resposta inflamatória ao LPS de células micróglia-símile ...
Cordeiro, Rafaela CarneiroSchizophrenia is one of the most complex and poorly understood psychiatric disorders, due to its heterogeneity of clinical presentation, which can lead to a progressive functional decline of the patient that impacts the cognitive, affective, and social domains, as well as the multiplicity of genetic and environmental risk factors in its pathophysiology. Findings point to the neurodevelopmental nature of schizop...
Leptin prevents lipopolysaccharide-induced depressive-like behaviors in mice: i...
Cordeiro, Rafaela Carneiro; Chaves Filho, Adriano José Maia; Medeiros, Camila Dantas; Queiroz, Ana Isabelle de Góis; Maes, Michael; Macedo, Danielle S.Depression is a chronic and recurrent disorder, associated with high morbidity and risk of suicide. Leptin was firstly described as an anti-obesity hormone, but several actions of leptin in CNS have been reported. In fact, leptin regulates dopaminergic neurotransmission in mesolimbic areas and has antidepressant-like properties in stress-based models. In the present study, we investigated, for the first time, p...
Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- an...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Chaves Filho, Adriano José Maia; Lima, Camila Nayane de CarvalhoEarly-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic...
Envolvimento de mecanismos dopaminérgicos na atividade antidepressiva da leptin...
Cordeiro, Rafaela CarneiroDepression is a chronic and recurrent disorder, whose prevalence in the general population is between 3-11%, being highly disabling and associated with increased morbidity due to medical reasons and risk of suicide. The discovery of new antidepressants with different action mechanisms is expected, with the hope that there is an increase in remission rates associated with the pharmacological treatment of depress...
Prevention and reversal of ketamine-induced schizophrenia related behavior by m...
Monte, Aline Santos; Souza, Greicy Coelho de; McIntyre, Roger S.; Soczynska, Joanna K.; Santos, Júnia Vieira dos; Cordeiro, Rafaela CarneiroIt has been hypothesized that oxidative imbalance and alterations in nitrergic signaling play a role in the neurobiology of schizophrenia. Preliminary evidence suggests that adjunctive minocycline treatment is efficacious for cognitive and negative symptoms of schizophrenia. This study investigated the effects of minocycline in the prevention and reversal of ketamine-induced schizophrenia-like behaviors in mice...
Time course of the effects of lipopolysaccharide on prepulse inhibition and bra...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Cordeiro, Rafaela Carneiro; Araújo, Fernanda Yvelize Ramos de; Chaves, João HenriqueThe systemic administration of lipopolysaccharide (LPS) induces time-dependent behavioral alterations, which are related to sickness behavior and depression. The time-course effects of LPS on prepulse inhibition (PPI) remain unknown. Furthermore, the time-dependent effects of LPS on central nitrite content had not been investigated. Therefore, we studied alterations induced by single LPS (0.5 mg/kg, i.p.) admin...