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In vivo study of the effect of sugarcane bagasse lignin supplementation on broi...

Carvalho, Nelson Mota de; Souza, Carla Giselly de; Costa, Célia Maria; Castro, Cláudia; Fangueiro, Joana F.; Horta, Bruno; Outor-Monteiro, Divanildo

Since the global restrictions on antibiotics in poultry systems, there has been a growing demand for natural and sustainable feed additives for disease prevention and poultry nutrition. This study evaluated the effects of incorporating sugarcane bagasse (SCB) lignin into broiler chicken diets. The performance of the chickens, including body weight, feed intake, and mortality, as well as intestinal histomorphome...


From sugarcane to skin: lignin as a multifunctional ingredient for cosmetic app...

Antunes, Filipa; Mota, Inês F.; Fangueiro, Joana F.; Lopes, Graciliana; Pintado, Manuela; Costa, Patrícia Santos

Lignin has been suggested as a promising candidate for cosmetic applications due to its remarkable potential to absorb ultraviolet rays and distinctive antioxidant activity. This study aims at evaluating the performance of lignin from sugarcane bagasse (SCB) as natural UV blocker, antioxidant, and pigment. Lignin was extracted from SCB, characterized and incorporated into a blemish balm (BB) cream. The biologic...


Lignin from sugarcane bagasse as a prebiotic additive for poultry feed

Fangueiro, Joana F.; Carvalho, Nelson Mota de; Antunes, Filipa; Mota, Inês F.; Pintado, Manuela Estevez; Madureira, Ana Raquel; Costa, Patrícia Santos

Diet is a crucial factor on health and well-being of livestock animals. Nutritional strengthening with diet formulations is essential to the livestock industry and animal perfor-mance. Searching for valuable feed additives among by-products may promote not only circular economy, but also functional diets. Lignin from sugarcane bagasse was proposed as a potential prebiotic additive for chickens and incorporated ...


Sugarcane light-colored lignin: a renewable resource for sustainable beauty

Mota, Inês F.; Antunes, Filipa; Fangueiro, Joana F.; Costa, Carina A. E.; Rodrigues, Alírio E.; Pintado, Manuela E.; Costa, Patrícia S.

Lignin has emerged as a promising eco-friendly multifunctional ingredient for cosmetic applications, due to its ability to protect against ultraviolet radiation and its antioxidant and antimicrobial properties. However, its typical dark color and low water solubility limit its application in cosmetics. This study presents a simple process for obtaining light-colored lignin (LCLig) from sugarcane bagasse (SCB) a...


Physicochemical and biopharmaceutical aspects influencing skin permeation and r...

Souto, Eliana; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.

The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...


Physicochemical and biopharmaceutical aspects influencing skin permeation and r...

Souto, Eliana B.; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.

The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...


Biomimetic surface topography from the rubus fruticosus leaf as a guidance of a...

Monteiro, Nelson O.; Oliveira, Catarina; Silva, Tiago H.; Martins, Albino; Fangueiro, Joana F.; Reis, R. L.; Neves, N. M.

The promotion of angiogenesis is a fundamental step for efficient organ/tissue reconstitution and replacement. Thus, several strategies to promote vascularization of scaffolds were studied to satisfy this unsolved clinical need. The interface between cells and substrates is a determinant for the success of tissue engineering (TE) strategies. Substrateâ s topography is reported to play a key role in influencing ...


Diabetic Retinopathy and Ocular Melanoma: How Far We Are?

Souto, Eliana B.; Campos, Joana R.; Ana, Raquel da; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, Massimo

Diabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal m...


Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy...

Souto, Selma B.; Campos, Joana R.; Fangueiro, Joana F.; Silva, Amélia M.; Cicero, Nicola; Lucarini, Massimo; Durazzo, Alessandra; Santini, Antonello

A major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pancreatic -cells, being secreted in similar amounts as insulin. The biological activity of human ...


Diabetic retinopathy and ocular melanoma: how far we are?

Souto, Eliana B.; Campos, Joana R.; Da Ana, Raquel; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, Massimo

Diabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal m...


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