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The renin-angiotensin system in healthy human platelets: expressed but inactive
Panosetti, François; Cuenot, François M.; Auguste, Damian S. Saint; Martins Cavaco, Ana Cláudia; Nunes, Allancer D. C.; Lu, Philip H. J.Platelets play a crucial role in arterial thrombus formation, offering potential for new antiplatelet therapies with reduced bleeding risk. Here, we investigated the role of the renin-angiotensin system (RAS) in human platelets and explored its potential link to COVID-19 coagulopathy. Experiments were performed ex vivo on healthy human platelets. The expression of RAS receptors (Mas, MrgD, ACE, ACE2, AT1 and AT...
A randomized controlled trial assessing the release of circulating tumor and me...
Leitão, Tito Palmela; Corredeira, Patrícia; Rodrigues, Carolina; Piairo, Paulina; Miranda, Miguel; Martins Cavaco, Ana Cláudia; Kucharczak, SandraAbstract: Background: Circulating tumor cells (CTCs) may be the missing renal cell carcinoma (RCC) biomarker. No-touch (NT) resection has shown benefit in several tumors. Methods: A randomized controlled trial comparing CTC and circulating mesenchymal cell (CMC) release in no-touch (NT) vs. conventional (C) laparoscopic RN. Blood samples were collected at operation room arrival (S0), specimen extraction (S1), p...
Clinical validation of a size-based microfluidic device for circulating tumor c...
Palmela Leitão, Tito; Corredeira, Patrícia; Kucharczak, Sandra; Rodrigues, Margarida; Piairo, Paulina; Rodrigues, Carolina; Alves, PatríciaRenal cell carcinoma (RCC) presents as metastatic disease in one third of cases. Research on circulating tumor cells (CTCs) and liquid biopsies is improving the understanding of RCC biology and metastases formation. However, a standardized, sensitive, specific, and cost-effective CTC detection technique is lacking. The use of platforms solely relying on epithelial markers is inappropriate in RCC due to the freq...