3 documents found, page 1 of 1
Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in...
Bielefeld, P; Martirosyan, A; Martín-Suárez, S; Apresyan, A; Meerhoff, GF; Pestana, F; Poovathingal, S; Reijner, N; Koning, W; Clement, RA; Veen, IVdTraumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult hippocampus harbors neural stem cells (NSCs) that generate neurons (neurogenesis), and astrocytes (astrogliogenesis). While deregulation of hippocampal NSCs and neurogenesis have been observed after TBI, it is not known how TBI may aff...
Unravelling cell type-specific responses to Parkinson's Disease at single cell ...
Martirosyan, A; Ansari, R; Pestana, F; Hebestreit, K; Gasparyan, H; Aleksanyan, R; Hnatova, S; Poovathingal, S; Marneffe, C; Thal, DR; Kottick, AParkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the substantia nigra pars compacta (SNpc) of the midbrain. However, the molecular mechanisms that underlie the pathology in different cell types is not currently understood. Here, we present a single nucleus transc...
Molecular and cognitive signatures of ageing partially restored through synthet...
Lemaitre, P; Tareen, SH; Pasciuto, E; Mascali, L; Martirosyan, A; Callaerts-Vegh, Z; Poovathingal, S; Dooley, J; Holt, MG; Yshii, L; Liston, ACognitive decline is a common pathological outcome during aging, with an ill-defined molecular and cellular basis. In recent years, the concept of inflammaging, defined as a low-grade inflammation increasing with age, has emerged. Infiltrating T cells accumulate in the brain with age and may contribute to the amplification of inflammatory cascades and disruptions to the neurogenic niche observed with age. Recen...