10 documents found, page 1 of 1
Intravenous thrombolysis versus endovascular thrombectomy in acute basilar arte...
Räty, Silja; Strambo, Davide; Gomez-Exposito, Alexandra; Marto, João Pedro; Ramos, João Nuno; Krebs, Stefan; Virtanen, Pekka; Ritvonen, JuhaniFunding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was supported by Helsinki University Hospital governmental subsidiary funds for clinical research (S.R., P.J.L., D.Strbian). Publisher Copyright: © 2025 World Stroke Organization.; Background: Randomized controlled trials have demonstrated an improve...
Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts mac...
Marques, André R.A.; Ferreira, Inês; Ribeiro, Quélia; Ferraz, Maria J.; Lopes, Elizeth; Pinto, Daniela; J. Hall, Michael; JS, Ramalho; Artola, MartaAtherosclerosis can be described as a local acquired lysosomal storage disorder (LSD), resulting from the build-up of undegraded material in lysosomes. Atherosclerotic foam cells accumulate cholesterol (Chol) and glycosphingolipids (GSLs) within lysosomes. This constitutes the ideal milieu for the formation of a side product of lysosomal storage: glucosylated cholesterol (GlcChol), previously found in several L...
Early diagnosis and complications of Acute Ischemic Stroke
Marto, João PedroAbstract Stroke is the first cause of death and disability in Portugal, and the second cause of death and third cause of disability worldwide. In patients with stroke, treatment interventions are time-dependent, meaning that shorter time from stroke onset to treatment is associated with better outcomes. Blood-based biomarkers represent a potential alternative to neuroimaging for early and rapid stroke diagnosis...
Basilar artery occlusion management: specialist perspectives from an internatio...
Edwards, Christopher; Drumm, Brian; Siegler, James E.; Schonewille, Wouter J.; Klein, Piers; Huo, Xiaochuan; Chen, Yimin; Abdalkader, MohamadBackground and purpose: Two early basilar artery occlusion (BAO) randomized controlled trials did not establish the superiority of endovascular thrombectomy (EVT) over medical management. While many providers continue to recommend EVT for acute BAO, perceptions of equipoise in randomizing patients with BAO to EVT versus medical management may differ between clinician specialties. Methods: We conducted an intern...
Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular ev...
Nguyen, Thanh N.; Qureshi, Muhammad M.; Klein, Piers; Yamagami, Hiroshi; Mikulik, Robert; Czlonkowska, Anna; Abdalkader, Mohamad; Sedova, PetraBackground and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of str...
Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal
Dias, Mariana Carvalho; Reis, Ricardo Soares dos; Santos, João Vasco; Nunes, Ana Paiva; Ferreira, Patricia; Maia, Bruno; Fragata, Isabel; Reis, JoaoIntroduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular ...
Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal
Dias, Mariana Carvalho; dos Reis, Ricardo Soares; Santos, João Vasco; Nunes, Ana Paiva; Ferreira, Patricia; Maia, Bruno; Fragata, Isabel; Reis, JoaoIntroduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular ...
Global impact of COVID-19 on stroke care and IV thrombolysis
Nogueira, Raul G.; Qureshi, Muhammad M.; Abdalkader, Mohamad; Martins, Sheila Ouriques; Yamagami, Hiroshi; Qiu, Zhongming; Mansour, Ossama YassinObjective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified ...
Intravenous thrombolysis for acute ischemic stroke after recent myocardial infa...
Marto, João Pedro; Azevedo Kauppila, Linda; Jorge, Cláudia; Calado, Sofia; Viana-Baptista, Miguel; Melo, Teresa Pinho e; Fonseca, Ana CatarinaBackground and Purpose- The safety of IV r-tPA (intravenous tissue-type plasminogen activator) for acute ischemic stroke (AIS) treatment after recent myocardial infarction (MI) is still a matter of debate. We studied the safety of delivering IV r-tPA to AIS patients with a MI within the preceding 3 months. Methods- Retrospective review of consecutive AIS admitted to 2 tertiary university hospitals' and systemat...
Patients with undetermined stroke have increased atrial fibrosis : a cardiac ma...
Fonseca, Ana Catarina; Alves, Pedro; Inácio, Nuno; Marto, João Pedro; Viana-Baptista, Miguel; Melo, Teresa Pinho e; Ferro, José; Almeida, Ana G.Background and Purpose—Some patients with ischemic strokes that are currently classified as having an undetermined cause may have structural or functional changes of the left atrium (LA) and left atrial appendage, which increase their risk of thromboembolism. We compared the LA and left atrial appendage of patients with different ischemic stroke causes using cardiac magnetic resonance imaging. Methods—We prospe...