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Global age-sex-specific mortality, life expectancy, and population estimates in...
Schumacher, AE; Kyu, HH; Aali, A; Abbafati, C; Abbas, J; Abbasgholizadeh, R; Abbasi, MA; Abbasian, M; Abd ElHafeez, S; Abdelmasseh, M; Abd Elsalam, SBackground: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides n...
Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials
Das, G; Shin, HS; Leyva-Gómez, G; Prado-Audelo, MLD; Cortes, H; Singh, YD; Panda, MK; Mishra, AP; Nigam, M; Saklani, S; Chaturi, PK; Martorell, MIn recent decades, interest in the Cordyceps genus has amplified due to its immunostimulatory potential. Cordyceps species, its extracts, and bioactive constituents have been related with cytokine production such as interleukin (IL)-1ß, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-a, phagocytosis stimulation of immune cells, nitric oxide production by increasing inducible nitric oxide synthas...
Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
Ramírez-Alarcón, K; Victoriano, M; Mardones, L; Villagran, M; Al-Harrasi, A; Al-Rawahi, A; Martins, N; Sharifi-Rad, J; Martorell, MType 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired ß-pancreatic cell function and insulin secretion, hyperglycemia and insulin resistance, and recently the epigenetic regulation of ß-pancreat...
Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Manag...
Sharifi-Rad, J; Quispe, C; Rahavian, A; Pereira Carneiro, JN; Rocha, JE; Alves Borges Leal, AL; Bezerra Morais Braga, MF; Melo Coutinho, HDSexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative review aims to present updated information about the use of natural bioactive compounds for the prevention and treatment of sexually transmitted infections. A search of the literature was perf...
Quercetin Impact in Pancreatic Cancer: An Overview on Its Therapeutic Effects
Asgharian, P; Tazehkand, AP; Soofiyani, SR; Hosseini, K; Martorell, M; Tarhriz, V; Ahangari, H; Martins, N; Sharifi-Rad, J; Almarhoon, ZM; Ydyrys, APancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing worldwide. Diagnosis of this cancer is complicated, as it does not often present symptoms, and most patients present an irremediable tumor having a 5-year survival rate after diagnosis. Regarding treatment, many concerns have also been raised, as most tumors are found at advanced stages. At present, anticancer com...
Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredient...
Sharifi-Rad, J; Quispe, C; Zam, W; Kumar, M; Cardoso, SM; Pereira, OR; Ademiluyi, AO; Adeleke, O; Moreira, AC; Živkovic, J; Noriega, F; Ayatollahi, SACardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor-alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and ...
Chitosan nanoparticles as a promising tool in nanomedicine with particular emph...
Sharifi-Rad, J; Quispe, C; Butnariu, M; Rotariu, LS; Sytar, O; Sestito, S; Rapposelli, S; Akram, M; Iqbal, M; Krishna, A; Kumar, NVA; Braga, SSThe study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding ...
Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literatu...
Islam, MT; Quispe, C; Herrera-Bravo, J; Sarkar, C; Sharma, R; Garg, N; Fredes, LI; Martorell, M; Alshehri, MM; Sharifi-Rad, J; Dastan, SD; Calina, DDengue remains one of the most serious and widespread mosquito-borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths. Dengue virus infection is especially transmitted through bites of Aedes mosquitos, hugely spread in tropical and subtropical envi...
Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Base...
Hossain, R; Quispe, C; Herrera-Bravo, J; Islam, MS; Sarkar, C; Islam, MT; Martorell, M; Martins, N; Al-Harrasi, A; Al-Rawahi, A; Sharifi-Rad, JLasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, a...
Chemical Composition, Biological Activity, and Health-Promoting Effects of With...
Sharifi-Rad, J; Quispe, C; Ayatollahi, SA; Kobarfard, F; Staniak, M; Stepien, A; Czopek, K; Sen, S; Acharya, K; Matthews, KR; Sener, B; Devkota, HPThe Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as...