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Enzyme Promiscuity in Serotonin Biosynthesis, From Bacteria to Plants and Humans

Gonçalves, Sara; Nunes-Costa, Daniela; Cardoso, Sandra Morais; Empadinhas, Nuno; Marugg, John David

Serotonin is a phylogenetically ancient compound found in animals, plants, and some bacteria. In eukaryotes, serotonin is synthesized from the aromatic amino acid tryptophan via the key enzymes aromatic amino acid hydroxylase (AAAH) and aromatic amino acid decarboxylase (AAAD). Serotonin is also an intermediate in the melatonin biosynthetic pathway and is involved in several vital functions. In humans, serotoni...


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