5 documents found, page 1 of 1
Bringing hope to improve treatment in pancreatic ductal adenocarcinoma - a new ...
Bravo, Ana Catarina; Morão, Bárbara; Luz, André; Dourado, Rúben; Oliveira, Beatriz; Guedes, Ana; Moreira-Barbosa, Catarina; Fidalgo, CatarinaBackground/Objectives: Pancreatic ductal adenocarcinoma (PDAC) incidence is rising, and prognosis remains poor due to late diagnosis and limited effective therapies. Currently, patients are treated based on TNM staging, without molecular tumor characterization. This study aimed to validate a technique that combines the amplification refractory mutation system (ARMS) with high-resolution melting analysis (HRMA) ...
EBV and MSI status in gastric cancer: does it matter?
Nascimento, Catarina Neto do; Mascarenhas-Lemos, Luís; Silva, João Ricardo; Marques, Diogo Sousa; Gouveia, Catarina Ferreira; Faria, Ana; Velho, SóniaWe investigated the impactof microsatellite instability (MSI) and Epstein–Barr virus (EBV) status in gastric cancer (GC), regarding response to perioperative chemotherapy (POPChT), overall survival (OS), and progression-free survival (PFS). We included 137 cases of operated GC, 51 of which were submitted to POPChT. MSI status was determined by multiplex PCR and EBV status by EBV-encoded RNA in situ hybridizatio...
Role of endoscopic biopsies and morphologic features in predicting microsatelli...
Silva, João R.; Mascarenhas-Lemos, Luís; Neto do Nascimento, Catarina; Sousa Marques, Diogo; Wen, Xiaogang; Pinho, Lídia; Maio, Rui; Pontes, PatríciaEvaluation of mismatch repair (MMR) protein and microsatellite instability (MSI) status plays a pivotal role in the management of gastric cancer (GC) patients. In this study, we aimed to evaluate the accuracy of gastric endoscopic biopsies (EBs) in predicting MMR/MSI status and to uncover histopathologic features associated with MSI. A multicentric series of 140 GCs was collected retrospectively, in which EB an...
EBV and MSI status in gastric cancer: does it matter?
do Nascimento, Catarina Neto; Mascarenhas-Lemos, Luís; Silva, João Ricardo; Marques, Diogo Sousa; Gouveia, Catarina Ferreira; Faria, Ana; Velho, SóniaWe investigated the impactof microsatellite instability (MSI) and Epstein-Barr virus (EBV) status in gastric cancer (GC), regarding response to perioperative chemotherapy (POPChT), overall survival (OS), and progression-free survival (PFS). We included 137 cases of operated GC, 51 of which were submitted to POPChT. MSI status was determined by multiplex PCR and EBV status by EBV-encoded RNA in situ hybridizatio...
Brachial Plexus Morphology and Vascular Supply in the Wistar Rat
Angélica-Almeida, Maria; Casal, Diogo; Mafra, Manuela; Mascarenhas-Lemos, Luís; Martins-Ferreira, José; Ferraz-Oliveira, Mário; Amarante, JoséIntroduction: The rat is probably the animal species most widely used in experimental studies on nerve repair. The aim of this work was to contribute to a better understanding of the morphology and blood supply of the rat brachial plexus.Material and Methods: Thirty adult rats were studied regarding brachial plexus morphology and blood supply. Intravascular injection and dissection under an operating microscope...