2 documents found, page 1 of 1
Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia...
Silva, Ana Teresa; Almeida, Afonso R. M.; Cachucho, Ana; Neto, João L.; Demeyer, Sofie; de Matos, Mafalda; Hogan, Thea; Li, Yunlei; Meijerink, JulesU117573801 MR/P011225/1 ERC CoG-648455 KiKa 2010-082; Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL). Although a subset of patients with T-ALL display high IL7R messenger RNA levels and cases with IL7R gains have been reported, the impact of IL-7Rα overexpression, rather than mut...
Interleukin-7 receptor α mutational activation can initiate precursor B-cell ac...
Almeida, Afonso R.M.; Neto, João L.; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta B.; Raposo, BeatrizInterleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, establishes a pre-leukemic stage in which B-cell precursors display self-renewal a...