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Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes

Moreira Da Silva, Rodrigo; De Gaitani, Cristiane Masetto; Marques, Lucas Maciel Mauriz; Fraige Baraco, Karina; Cavalheiro, Alberto José

Made available in DSpace on 2022-04-29T08:45:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of Casearia sylvestris and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for in vivo antitumor action have also been described when CAS X was administered intraperi...

Data: 2022   |   Origem: Oasisbr

Aromatic compounds from three brazilian lauraceae species

Batista, Andrea Nastri Luca de; Batista, J. M.; López, Silvia Noelí; Furlan, Maysa; Cavalheiro, Alberto José; Silva, Dulce Helena Siqueira

Phytochemical investigations on three Brazilian Lauraceae species from, the Cerrado region of São Paulo State, Ocotea corymbosa (Meins) Mez., O. elegans Mez. and Persea pyrifolia Nees & Mart. ex Nees resulted in the isolation of flavonoids, an ester of the 4-O-E-caffeoylquinic acid, an aromatic sesquiterpene besides furofuran lignans. This is the first chemical study on the leaves of Ocotea elegans and O. corym...

Data: 2020   |   Origem: Oasisbr

Counteracting effects on free radicals and histological alterations induced by ...

Araújo, Éverton José Ferreira de; Oliveira, Guilherme Antônio Lopes de; Sousa, Lívia Queiroz de; Bolzani, Vanderlan da Silva; Cavalheiro, Alberto José

Casearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis -clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. ...

Data: 2016   |   Origem: Oasisbr


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